台大食品科技研究所

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沈立言
职称 特聘教授
姓名 沈立言
联络电话 02-3366-4129
电子邮件
学历 国立中兴大学食品科学研究所 博士 ( 1990 ) （含美国罗格斯大学食品科学研究所公费留学）
研究专长 预防医学、食疗研究、保健食品、食品安全
个人网址 https://fo93316.wixsite.com/website
2023 Huang, H.S., Lin, Y.E., Panyod, S., Chen, R.A., Lin, Y.C., Chai, L.M.C., Hsu, C.C., Wu, W.K., Lu, K.H., Huang, Y.J., Sheen, L.Y.* 2023. Anti-depressive-like and cognitive impairment alleviation effects of Gastrodia elata Blume water extract is related to gut microbiome remodeling in ApoE-/- mice exposed to unpredictable chronic mild stress. Journal of Ethnopharmacology. 302 (Part B): 115872.
2023 Chou, T.W., Huang, H.S., Panyod, S., Huang, Y.J., Sheen, L.Y.* 2023. Korean red ginseng water extract produces antidepressant-like effects through involving monoamines and brain-derived neurotrophic factor in rats. Journal of Ginseng Research. 47 (4): 522-560.
2023 Ho, C.T.*, Wu, M.S., Panyod, S., Chang, A.C., Isidoro, C., Sheen, L.Y. 2023. Editorial note: Gut microbiota and health. Journal of Traditional and Complementary Medicine. 13 (2): 105-106.
2023
Panyod, S., Wu, W.K., Peng, S.Y., Tseng, Y.J., Hsieh, Y.C., Chen, R.A., Huang, H.S., Chen, Y.H., Chuang, H.L., Hsu, C.C., Shen, T.D., Yang, K.C., Ho, C.T., Wu, M.S.*, Sheen, L.Y.* 2023. Ginger essential oil and citral ameliorates atherosclerosis in ApoE-/- mice by modulating trimethylamine-N-oxide and gut microbiota. npj Science of Food. 20; 7 (1), 19.
2023 Huang, Y.J., Tsai, M.S., Panyod, S., Liu, P.Y., Lu, K.H., Weng, C.Y., Huang, H.S., Hsu, C.C, Sheen, L.Y.* 2023. Garlic essential oil ameliorates depression-like behaviors in unpredictable chronic mild stress through modulating brain NLRP3 inflammasome pathway and influencing gut barrier and microbiota. Food & Function. 31;14(15):6998-7010
2023
Panyod, S., Wu, W.K., Hu, M.Y., Huang, S.H., Chen, R.A., Chen, Y.H., Shen, T.C.D., Ho, C.T., Liu, C.J., Chuang, H.L., Huang, C.C., Wu, M.S., Sheen, L.Y. 2023. Healthy diet intervention reverses the progression of NASH through gut microbiota modulation. Microbiology Spectrum. 12(1): e0186823.
2023
Lu, K.H., Hsu, A., Pan, Y.C., Huang, Y.J., Goh, L.Y., Kang, C.Y., Sheen, L.Y. Modeling the temperature effect on the growth of Uropathogenic Escherichia coli in sous-vide chicken breast. Foodborne Pathog Dis. 20 (8): 343-350
2022 Panyod, S., Wu, W.K., Chen, P.C., Chong, K.V., Yang, Y.T., Chuang, H.L., Chen, C.C., Chen, R.A., Liu, P.Y., Chung, C.H., Huang, H.S., Lin, A. Y.C., Shen, T.C. D., Yang, K.C., Huang, T.F., Hsu, C.C., Ho, C.T., Kao, H.L., Orekhov, A.N., Wu, M.S.* and Sheen, L.Y.* 2022. Atherosclerosis amelioration by allicin in raw garlic through gut microbiota and trimethylamine-N-oxide modulation. npj Biofilms and Microbiomes, 8: 4.
2022 Chai, H.E., Hwang, C.A.*, Huang L., Wu, V.C.H. and Sheen, L.Y. 2022. Efficacy of gaseous chlorine dioxide for decontamination of Salmonella, Shiga toxin-producing Escherichia coli, and Listeria monocytogenes on almonds and peppercorns. Food Control. 132, 108556.
2022 Isidoro, C.*, Chang, A.C.F. and Sheen, L.Y. 2022. Natural products as a source of novel drugs for treating SARS-CoV2 infection. Journal of Traditional and Complementary Medicine. 12(1), 1-5.
2022 Chang, H.P., Huang, M.C., Lei, Y.P., Chuang, Y.J., Wang, C.W. and Sheen, L.Y.* 2022. Phytochemical-rich vegetable and fruit juice alleviates oral mucositis during concurrent chemoradiotherapy in patients with locally advanced head and neck cancer, Journal of Traditional and Complementary Medicine.
2022 Chen, R.A., Wu, W.K., Panyod, S., Liu, P.Y., Chuang, H.L., Chen, Y.H., Lyu, Q., Hsu, H.C., Lin, T.L., Shen T.C., Yang, Y.T., Zou, H.B., Huang, H.S., Lin, Y.E., Chen, C.C., Ho, C.T., Lai, H.C., Wu, M.S, Hsu, C.C. and Sheen, L.Y.* 2022. Dietary exposure to antibiotic residues facilitates metabolic disorder by altering the gut microbiota and bile acid composition. mSystems, 7(3) e00172-22.
2022 Lin, Y.E., Lin, M.H., Yeh, T.Y., Lai, Y.S., Lu, K.H., Huang, H.S., Peng, F.C., Liu, S.H. and Sheen, L.Y.* 2022. Genotoxicity and 28-day repeated dose oral toxicity study of garlic essential oil in mice. Journal of Traditional and Complementary Medicine.
2022 Huang, H.S., Lin, Y.E., Panyod, S., Chen, R.A., Lin, Y.C., Chai, L.M.X., Hsu, C.C., Wu, W.K., Lu, K.H., Huang, Y.J. and Sheen, L.Y.* 2022. Anti-depressive-like and cognitive impairment alleviation effects of Gastrodia elata Blume water extract is related to gut microbiome remodeling in ApoE−/− mice exposed to unpredictable chronic mild stress. Journal of Ethnopharmacology.
2021 Huang, Y.J., Choong, L.X.C. Panyod, S., Lin, Y.E., Huang H.S., Lu K.H., Wu, W.K. and Sheen, L.Y.* 2021. Gastrodia elata Blume water extract modulates neurotransmitters and alters the gut microbiota in a mild social defeat stress-induced depression mouse model. Phytotherapy Research. 35, 5133-5142.
2021 Wu, W.K., Chen, Y.H., Lee, P.C., Yang, P.J., Chang, C.C., Liu, K.L., Hsu, C.C., Huang, C.C., Chuang, H.L., Sheen, L.Y., Liu, C.J. and Wu, M.S. 2021. Mining gut microbiota from bariatric surgery for MAFLD. Frontiers in Endocrinology. 12, 612946.
2021 Lin, Y.E., Chen, Y.C., Lu, K.H., Huang, Y.J., Panyod, S., Liu, W.T., Yang, S.H., Lu, Y.S., Chen, M.H. and Sheen, L.Y.* 2021. Antidepressant-like effects of water extract of Cordyceps militaris (Linn.) Link by modulation of ROCK2/PTEN/Akt signaling in an unpredictable chronic mild stress- induced animal model. Journal of Ethnopharmacology. 10(276), 114194.
2021 Lin, Y.E., Chen, Y.C., Ho, E.P., Ke, Y.C., Petridi S., Elliott, C.J., Sheen, L.Y. and Chien, C.T.* 2021. Glial Nrf2 signaling mediates the neuroprotection exerted by Gastrodia elata Blume in Lrrk2-G2019S Parkinson's disease. elife.10, 73753.
2021 Panyod, S., Wu, W.K., Chen, P.C., Chong, K.V., Yang, Y.T., Chuang, H.L., Chen, C.C., Chen, R.A., Liu, P.Y., Chung, C.H., Huang, H.S., Lin, A. Y.C., Shen, T.C. D., Yang, K.C., Huang, T.F., Hsu, C.C., Ho, C.T., Kao, H.L., Orekhov, A.N., Wu, M.S.* and Sheen, L.Y.* 2021. Atherosclerosis amelioration by allicin in raw garlic through gut microbiota and trimethylamine-N-oxide modulation. npj Biofilms and Microbiomes.
2020 Wu, W.K., Panyod, S., Liu, P.Y., Chen, C.C., Kao, H.L., Chuang, H.L., Chen, Y.H., Zou, H.C.,Kuo, H.C., Kuo, C.H., Liao, B.Y., Chiu, H.T., Chung, C.H., Lin, Y.C., Lee, Y.C., Tang, S.L., Wang, J.T., Wu, Y.W., Hsu, C.C., Sheen, L.Y., Orekhov, A.N., Wu, M.S. 2020. Characterization of TMAO productivity from carnitine challenge facilitates personalized nutrition and microbiome signatures discovery. Microbiome. 8:162.
2020 Lu, K.H., Sheen, Y.J., Huang, T.P., Kao, S.H., Cheng, C.L., Hwang, C.A., Sheen, S., Huang, L., Sheen, L.Y.* 2020. Effect of temperature on the growth of Staphylococcus aureus in ready-to-eat cooked rice with pork floss. Food Microbiology. 89, 103374.
2020 Panyod, S., Ho, C.T., Sheen, L.Y.* 2020. Dietary therapy and herbal medicine for COVID-19 prevention: A review and perspective. Journal of Traditional and Complementary Medicine.10(3), 260-267.
2020 Lu, K.H., Ou, G.L., Chang, H.P., Chen, W.C., Liu, S.H., Sheen, L.Y.* 2020. Safety evaluation of water extract of Gastrodia elata Blume: Genotoxicity and 28-day oral toxicity studies. Regulatory Toxicology and Pharmacology. 114, 104657.
2020
Wu, W.K., Hsu, C.C., Sheen, L.Y., Wu, M.S. 2020. Measurement of gut microbial metabolites in cardiometabolic health and translational research. Rapid Communications in Mass Spectrometry. 34(S1), e8537.
2020 Panyod, S., Sheen, L.Y.* 2020. Beneficial effects of Chinese herbs in the treatment of fatty liver diseases. Journal of Traditional and Complementary Medicine. 10(3), 260-267.
2020 Lu, K.H., Pan, Y.C., Sheen, L.Y.* 2020. Combination of cut-log cultivated fruiting body and solid-state cultured mycelia of Taiwanofungus camphoratus ameliorates CCL4-induced liver injury in rats. Journal of Traditional and Complementary Medicine. 10(2), 166-174.
2020 Panyod, S., Wu, W.K., Lu, K.H., Liu, C.T., Chu, Y.L., Ho, C.T., Wendy Hsiao, W.L., Lai, Y.S., Chen, W.C., Lin, Y.E., Lin, S.H., Wu, M.S., Sheen, L.Y.* 2020. Allicin modifies the composition and function of the gut microbiota in alcoholic hepatic steatosis mice. Journal of Agricultural and Food Chemistry. 68(10), 3088-3098.
2020 Chai, H.E., Hwang, C.A., Huang, L., Vivian Wu, C.H., Sheen, L.Y.* 2020. Feasibility and efficacy of using gaseous chlorine dioxide generated by sodium chlorite-acid reaction for decontamination of foodborne pathogens on produce. Food Control. 108, 106839.
2020 Lin, H.C., Sheu, S.Y., Sheen, L.Y., Sheu, P.W., Chiang, W., Kuo, T.F. 2020. The gastroprotective effect of the foxtail millet and adlay processing product against stress-induced gastric mucosal lesions in rats. Journal of Traditional and Complementary Medicine. 10(4), 336-344.
2020 Huang, Y.J., Hsu, N.Y., Lu, K.H., Lin, Y.E., Lin, S.H., Lu, Y.S., Liu, W.T., Chen, M.H., Sheen, L.Y.* 2020. Poria cocos water extract ameliorates the behavioral deficits induced by unpredictable chronic mild stress in rats by down-regulating inflammation. Journal of Ethnopharmacology. 258, 112566.
2020 Chuang, S., Sheen, S., Sommers, C., Zhou, S., Sheen, L.Y.* 2020. Survival evaluation of Salmonella and Listeria monocytogenes on selective and nonselective media in ground chicken meat subjected to high hydrostatic pressure and carvacrol. Journal of Food Protection. 83(1), 37-44.
2019 Wu, W.K., Sheen, L.Y.* and Wu, M.S.* 2019. Response to the letter: Identification of trimethylamine N-oxide (TMAO)-producer phenotype is interesting, but is it helpful? Gut, http://doi.10.1136/gutjnl-2018-318187.
2019 Lu, K.H., Lee, H.Y., Chu, Y.L., Ho, C.T. and Sheen, L.Y.* 2019. Bitter orange peel extract induces endoplasmic reticulum-mediated autophagy in human hepatoma cells. Journal of Functional Foods, 60: 103404.
2019 Chen, P.C., Wu, W.K., Panyod, S., Wu, M.S. and Sheen, L.Y.* 2019. Cardiovascular disease protective effect of allicin through gut microbiota modulation (FS07-08-19). Current Development in Nutrition (Supplement 1), 3: 1738-1739.
2019 Wu, W.K., Hsu, C.C., Sheen, L.Y.* and Wu, M.S. 2019. Measurement of gut microbial metabolites in cardiometabolic health and translational research. Rapid Communications in Mass Spectrometry, doi: 10.1002/rcm.8537.
2019 Chai, H.E., Hwang, C.A., Huang, L.H., Vivian Wu, C.H. and Sheen, L.Y.* 2019. Feasibility and efficacy of using gaseous chlorine dioxide generated by sodium chlorite-acid reaction for decontamination of foodborne pathogens on produce. Food Control, 108: 106839.
2019 Lu, K.H., Sheen, Y.J., Huang, T.P., Kao, S.H., Cheng, C.L., Hwang, C.A., Sheen, S., Huang, L. and Sheen, L.Y.* 2019. Effect of temperature on the growth of Staphylococcus aureus in ready-to-eat cooked rice with pork floss. Food Microbiology, https://doi.org/10.1016/j.fm. 2019.103374.
2019 Chuang, S., Sheen, S., Sommers, C., Zhou, S. and Sheen, L.Y.* 2019. Survival evaluation of Salmonella and Listeria monocytogenes on selective and nonselective media in ground chicken meat subjected to high hydrostatic pressure and carvacrol. Journal of Food Protection, 83(1): 37-44.
2019 Xu, A.X., Chuang, S.Y., Scullen, O.J., Huang, L.H., Sheen, S.S., Sheen, L.Y.*, Johnson, J.R., Sommers, C.H. 2019. Thermal inactivation of extraintestinal pathogenic Escherichia coli suspended in ground chicken meat. Food Control. 104: 269-277.
2019 Lu, K.H., Pan, Y.C., Sheen, L.Y.* 2019. Combination of cut-log cultivated fruiting body and solid-state cultured mycelia of Taiwanofungus camphoratus ameliorates CCl4-induced liver injury in rats. Journal of Traditional and Complementary Medicine.
2019 Chien, S.Y., Sheen, S.S., Sommers, C., Sheen, L.Y.* 2019. Combination effect of high-pressure processing and essential oil (Melissa officinalis extracts) or their constituents for the inactivation of Escherichia coli in ground beef. Food and Bioprocess Technology. 12(3): 359-370.
2019 Wu, W.K., Chen, C.C., Panyod, S., Chen, R.A., Wu, M.S., Sheen, L.Y.*, Chang, S.C. 2019. Optimization of fecal sample processing for microbiome study—the journey from bathroom to bench. Journal of the Formosan Medical Association. 118(2): 545-555.
2019 Wu, W.K., Chen, R.A., Panyod, S., Chen, C.C., Hsueh, P.R., Sheen, L.Y.*, Wu, M.S. 2018. The impact of veterinary antibiotic residue in foods on obesity and antibiotic resistance through modulation of gut microbiota. Journal of Gastroenterology and Hepatology. 33: 77-77.
2019 Huang, Y.J., Lu, K.H., Sheen, L.Y.* 2019. Garlic essential oil mediates acute and chronic mild stress-induced depression in rats via modulation of monoaminergic neurotransmission and brain-derived neurotrophic factor levels. Journal of Food & Function. (under review)
2018 Wu, W.K., Chen, C.C., Liu, P.U., Panyod, S., Liao, B.Y., Chen, P.C., Kao, H.L., Kuo, H.C., Kuo, C.H., Chiu, H.T., Chen, R.A., Chuang, H.L., Huang, H.T., Zou, H.B., Hsu, C.C., Chang, T.Y., Lin, C.L., Ho, C.T., Yu, H.T., Sheen, L.Y.*, Wu, M.S. 2018. Identification of TMAO-producer phenotype and host–diet–gut dysbiosis by carnitine challenge test in human and germ-free mice. Gut, doi:10.1136/gutjnl-2018-317155.
2018 Huang, C.Y., Sheen, S.*, Sommers, C., Sheen, L.Y.* 2018. Modeling the survival of Escherichia coli O157:H7 under hydrostatic pressure, process temperature, time and allyl isothiocyanate stresses in ground chicken meat. Frontiers in Microbiology, 9: 1871.
2018 Wang, P.S., Kuo, C.H., Yang, H.C., Liang, Y.J., Huang, C.J., Sheen, L.Y., Pan, W.H. 2018. Postprandial metabolomics response to various cooking oils in humans. Journal of Agricultural and Food Chemistry, 66(19): 4977-4984.
2018 Wu, W.K., Panyod, S., Chen, C.C., Kuo, H.C., Liu, P.Y., Kuo, C.H., Chen, R.A. Sheen, L.Y.*, Wu, M.S. 2018. 747 - Gavage of fecal microbiota from TMAO producer characterized by modified carnitine challenge test reproduces the TMAO formation phenotype in germ free mice. Gastroenterology, 154(6): 156-157.
2018 Lin, Y.E., Chou, S.T., Lin, S.H., Lu, K.H., Panyod, S., Lai, Y.S., Ho, C.T., Sheen, L.Y.* 2018. Antidepressant-like effects of water extract of Gastrodia elata Blume on neurotrophic regulation in a chronic social defeat stress model. Journal of Ethnopharmacology, 215: 132-139.
2018 Sommers, C., Huang, C. Y., Sheen, L.Y., Sheen, S., Huang, L. 2018. Growth modeling of uropathogenic Escherichia coli in ground chicken meat. Food Control, 86: 397-402.
2018 Lin, Y.E., Lu, K.H., Sheen, L.Y.* 2018. Recent research progress on the antidepressant-like effect and neuropharmacological potential of Gastrodia elata Blume. Current Pharmacology Reports, 4(3): 220-237.
2018 Wu, W.K., Chen, C.C., Panyod, S., Chen R.A., Wu, M.S., Sheen, L.Y.*, Chang, S.C. 2018. Optimization of fecal sample processing for microbiome study - The journey from bathroom to bench. Journal of the Formosan Medical Association, doi: 10.1016/j.jfma.2018.02.005.
2018 Cheng, B.H., Sheen, L.Y., Chang, S.T. 2018. Hypolipidemic effects of S-(+)-linalool and essential oil from Cinnamomum osmophloeum ct. linalool leaves in mice. Journal of Traditional and Complementary Medicine, 8(1): 46-52.
2018 Huang, H.L., Lim, S.L., Lu, K.H., Sheen, L.Y.* 2018. Antidepressant-like effects of Gan-Mai-Dazao-Tang via monoamine regulatory pathways on forced swimming test in rats. Journal of Traditional and Complementary Medicine, 8(1): 53-59.
2017 Lu, K.H., Weng, C.Y., Chen, W.C., Sheen, L.Y.* 2017. Ginseng essence, a medicinal and edible herbal formulation, ameliorates carbon tetrachloride-induced oxidative stress and liver injury in rats. Journal of Ginseng Research, 41(3): 316-325.
2017 Wang, H.C., Chu, Y.L., Hsieh, S.C., Sheen, L.Y.* 2017, Jun. Diallyl trisulfide inhibits cell migration and invasion of human melanoma A375 cells via inhibiting intergrin/facal adhision kinase pathway. Environmental Toxicology, 32(11): 2352-2359.
2016 Hsu, W.F., Sheen, L.Y., Lin, H.J., Chang, H.H. 2016. A review of western and traditional Chinese medical approaches to managing nonalcoholic fatty liver disease. Evidence-Based Complementary and Alternative Medicine, 2016:6491420. Epub 2016 Oct 31.
2016 Chien, S.Y., Sheen, S.*, Sommers, C., Sheen, L.Y. 2016. Modeling the inactivation of Escherichia coli O157:H7 and uropathogenic E. coli in ground beef by high pressure processing and citral. Food Control, 73: 672-680.
2016 Panyod, S., Wu, W.K., Ho, C.T., Lu, K.H., Liu, C.T., Chu, Y.L., Lai, Y.S., Chen, W.C., Lin, Y.E., Lin, S.H., Sheen, L.Y.* 2016. Diet supplementation with allicin protects against alcoholic fatty liver disease in mice by improving anti-inflammation and antioxidative functions. Journal of Agricultural and Food Chemistry, 64(38): 7104-7113.
2016 Huang, W.F., Hong, T.W., Wang, Y.J., Chen, K.C., Pei, J.C., Chuang, T.Y., Lai, W.S., Tsai, S.H., Chu, R., Chen, W.C., Sheen, L.Y., Takahasi, S., Ding, S.T., Shen, T.L. 2016. Ophiocordyceps formosana improves hyperglycemia and depression-like behavior in an STZ-induced diabetic mouse model. BMC Complementary and Alternative Medicine, 16(1): 310.
2016 Chien, S.Y., Sheen, S.*, Sommers, C.H., Sheen, L.Y. 2016. Modeling the inactivation of intestinal pathogenic Escherichia coli O157: H7 and uropathogenic E. coli in ground chicken by high pressure processing and thymol. Frontiers in Microbiology, 7(920): 1-11.
2016 Lin, Y.E., Lin, S.H., Chen, W.C., Ho, C.T., Lai, Y.S., Panyod, S., and Sheen, L.Y.* 2016. Antidepressant-like effects of water extract of Gastrodia elata Blume in rats exposed to unpredictable chronic mild stress via modulation of monoamine regulatory pathways. Journal of Ethnopharmacology, 187: 57-65.
2016 Lu, K.H., Pan, Y.C., Sheen, L.Y.* 2016. Reflection on food safety incidents in Taiwan: From crisis response to risk management. Journal of Chinese Dietary Culture (in Chinese), 12(1): 245-271.
2016 Lai, Y.S., Lee, W.C., Lin, Y.E., Ho, C.T., Lu, K.H., Lin, S.H., Panyod, S., Chu, Y.L., Sheen, L.Y.* 2016. Ginger essential oil ameliorates hepatic injury and lipid accumulation in high fat diet-induced nonalcoholic fatty liver disease. Journal of Agricultural and Food Chemistry, 64(10): 2062-2071.
2016 Chen, W.C., Lai, Y.S., Lin, S.H., Lu, K.H., Panyod, S., Ho, C.T., Sheen, L.Y.* 2016. Anti-depressant effects of Gastrodia elata Blume and its compounds, gastrodin and 4-hydroxybenzyl alcohol, involve the monoaminergic system and neuronal cytoskeletal remodeling processes. Journal of Ethnopharmacology, 182: 190-199.
2015 Lin, S.H, Chou, M.L., Chen, W.C., Lai, Y.S., Lu, K.H., Hao, C.W., Chu, Y.L., Sheen, L.Y.* 2015. Antidepressant-like activity of the water extract of Melissa officinalis L. in forced swimming test via regulation of the serotonergic neurotransmitter. Journal of Ethnopharmacology, 175: 266-272.
2015 Lai, Y.S., Chen, W.C., Kuo, T.C., Ho, C.T., Kuo, C.H., Tseng, Y, Lu, K.H., Lin, S.H. Panyod, S., Sheen, L.Y.* 2015. Mass spectrometry-based serum metabolomics of a C57BL/6J mouse model of high-fat diet induced nonalcoholic fatty liver disease development. Journal of Agricultural and Food Chemistry, 63(35): 7873-7884.
2015 Wu, W.K., Panyod, S., Ho, C.T., Kuo, C.H., Wu, M.S., Sheen, L.Y.* 2015. Dietary allicin reduces transformation of L-carnitine to TMAO through impact on gut microbiota. Journal of Functional Foods, 15: 408-417.
2015 Huang, L.Y., Chu, Y.L., Ho, C.T., Chung, J.G., Lai C.I., Su, Y.C., Kuo, Y.H., Sheen, L.Y.* 2015. Antcin K, an active triterpenoid from the fruiting bodies of basswood cultivated Antrodia cinnamomea, inhibits metastasis via suppression of integrin-mediated adhesion, migration, and invasion in human hepatoma cells. Journal of Agricultural and Food Chemistry, 63(18): 4561-4569.
2015 Chen, W.C., Lai, Y.S., Lu, K.H., Lin, S.H., Liao, L.Y., Ho, C.T., Sheen, L.Y.* 2015. Method development and validation for the HPLC assay of gastrodin in water extracts from different sources of Gastrodia elata Blume. Journal of Food and Drug Analysis, 23(4): 803-810.
2015 Cheng, B.H., Sheen, L.Y., Chang, S.T. 2015. Evaluation of anxiolytic potency of essential oil and S-(+)-linalool from Cinnamomum osmophloeum ct. linalool leaves in mice. Journal of Traditional and Complementary Medicine, 5(1): 27-34.
2015 Lu, K.H. and Sheen, L.Y.* 2015. How do consumers protect themselves from the impact of food safety incidents. Judicial Aspiration (in Chinese), 113: 25-29.
2014 Chen, P.B., Wang, H.C., Liu, Y.W., Lin, S.H., Chou, H.N., Sheen L.Y.* 2014. Immunomodulatory activities of polysaccharides from Chlorella pyrenoidosa in a mouse model of Parkinson’s disease. Journal of Functional Foods, 11: 103-113.
2014 Lin, S.H., Chen, W.C, Lu, K.H., Chen, P.J., Hsieh, S.C. Pan, T.M., Chen, S.T., Sheen, L.Y.* 2014. Down-regulation of Slit-Robo pathway mediating neuronal cytoskeletal remodeling processes facilitates the antidepressive-like activity of Gastrodia elata Blume. Journal of Agricultural and Food Chemistry, 62(43): 10493-10503.
2014 Chang, H.P., Sheen L.Y., Lei, Y.P. 2014. The protective role of carotenoids and polyphenols in patients with head and neck cancer. Journal of the Chinese Medical Association, 78(2): 89-95.
2014 Lai, Y.S., Chen, W.C., Ho, C.T., Lu, K.H., Lin, S.H., Tseng, H.C., Sheen, L.Y.* 2014. Garlic essential oil protects against obesity-triggered nonalcoholic fatty liver disease through modulation of lipid metabolism and oxidative stress. Journal of Agricultural and Food Chemistry, 62(25): 5897-5906.
2014 Lo, W.Y., Sheen, L.Y., Lo, Y.C., Hsieh, S.C. 2014. The effects of blackcurrant on anti-inflammation and prevention of allergic respiratory diseases syndrome. Journal of Agricultural Chemistry and Food Science, 52(1): 25-30.
2014 Lu, K.H., Tseng, H.C., Liu, C.T., Huang, C.J., Chyuanc, J.H., Sheen, L.Y.* 2014. Wild bitter gourd protects against alcoholic fatty liver in mice by attenuating oxidative stress and inflammatory responses. Food and Function, 5(5): 1027-1037.
2013 Liu, Y.T., Lo, Y.C., Hsieh, S.C., Sheen, L.Y.* 2013. The antioxidant activity of blackcurrant and its effects on Parkinson's disease and Alzheimer's disease. Nutrition Society of Taiwan (in Chinese), 38(4): 120-131.
2013 Chu, Y.L., Chimeddulam, D., Sheen, L.Y.*, Wu, K.Y. 2013. Probabilistic risk assessment of exposure to leucomalachite green residues from fish products. Food and Chemical Toxicology, 62: 770-776.
2013 Liu, C.T., Raghu, R., Lin, S.H., Wang, S.Y., Kuo, C.H., Tseng, Y.J., Sheen, L.Y.* 2013. Metabolomics of ginger essential oil against alcoholic fatty liver in mice. Journal of Agricultural and Food Chemistry, 61(46): 11231-11240.
2013 Chu, Y.L., Ho, C.T., Chung, J.G., Rajasekaran R., Lo Y.C., Sheen, L.Y.* 2013. Allicin induces anti-human liver cancer cells through the p53 gene modulating apoptosis and atophagy. Journal of Agricultural and Food Chemistry, 61: 9839-9848.
2013 Chen, S.F., Hu, T.M., Lan, T.H., Chiu, H.J., Sheen, L.Y.*, Loh, E.W. 2013. Severity of psychosis syndrome and change of metabolic abnormality in chronic schizophrenia patients: Severe negative syndrome may be related to a distinct lipid pathophysiology. European Psychiatry, 29(3): 167-171.
2013 Chu, Y.L., Rajasekaran, R., Lu, K.H., Liu, C.T., Lin, S.H., Lai, Y.S., Chen, W.C., Lin, S.H., Sheen, L.Y.* 2013. Autophagy therapeutic potential of garlic in human cancer therapy. Journal of Traditional and Complementary Medicine, 3(3): 159-162.
2013 Lin, S.H., Chang, H.C., Chen, P.J., Hsieh, C.L., Su, K.P., Sheen, L.Y.* 2013. The antidepressant-like effect of ethanol extract of daylily flowers (金针花 Jīn Zhēn Huā ) in rats. Journal of Traditional and Complementary Medicine, 3(1): 53-61.
2012 Raghu R., Liu, C.T., Tsai, M.H., Tang, X., Kalari, K.R., Subramanian, S., and Sheen, L.Y.* 2012. Transcriptome analysis of garlic induced hepatoprotection against alcoholic fatty liver. Journal of the Agricultural and Food Chemistry 60(44): 11104-11119.
2012 Wu, C.C., Chu, Y.L., and Sheen, L.Y.* 2012. Allicin modulates the antioxidation and detoxification capability in primary rat hepatocytes. Journal of Traditional and Complementary Medicine 2(4): 323-330.
2012 Su, Y.C., Liu, C.T., Raghu, R., Kuo, Y.H., and Sheen, L.Y.* 2012. Eburicoic acid, an active triterpenoid from the fruiting bodies of basswood cultivated Antrodia cinnamomea, induces ER stress-mediated autophagy in human hepatoma cells. Journal of Traditional and Complementary Medicine 2(4): 312-322.
2012 Liu, Y.W., Lu, K.H., Ho, C.T., and Sheen, L.Y.* 2012. Protective effects of Antrodia cinnamomea against liver injury. Journal of Traditional and Complementary Medicine 2(4): 284-294.
2012 Wang H.C., Pao, J., Lin, S.Y., and Sheen, L.Y.* 2012. Molecular mechanisms of garlic-derived allyl sulfides in the inhibition of skin cancer progression. Annals of the New York Academy of Sciences 1271(1): 44-52.
2012 Chu, Y.L., Ho, C.T., Chung, J.G., Raghu, R., and Sheen, L.Y.* 2012. Allicin induces p53-mediated autophagy in Hep G2 human liver cancer cells. Journal of the Agricultural and Food Chemistry 60(34): 8363-8371.
2012 Raghu, R., Lu, K.H., and Sheen, L.Y.* 2012. Recent research progress on garlic (大蒜 dà suàn) as a potential anticarcinogenic agent against major digestive cancers. Journal of Traditional and Complementary Medicine 2(3): 192-201.
2012 Lu, K.H., Liu, C.T., Raghu, R., and Sheen, L.Y.* 2012. Therapeutic potential of Chinese herbal medicines in alcoholic liver disease. Journal of Traditional and Complementary Medicine 2(2): 115-122.
2012 Liu, C.T., Hsu, T.W., Chen, K.M., Tan, Y.P., Lii, C.K., and Sheen, L.Y.* 2012. The antidiabetic effect of garlic oil is associated with ameliorated oxidative stress but not ameliorated level of pro-inflammatory cytokines in skeletal muscle of streptozotocin-induced diabetic rats. Journal of Traditional and Complementary Medicine 2(2): 135-144.
2012 Tsai, C.W., Chen, H.W., Sheen, L.Y., and Lii, C.K. 2012. Garlic: Health benefits and actions. BioMedicine 2(1): 17-29.
2012 Tung, Y.C., Su, Z.Y., Kuo, M.L., and Sheen, L.Y.* 2012. Ethanolic extract of Agaricus blazei fermentation product inhibits the growth and invasion of human hepatoma HA22T/VGH and SK-Hep-1 cells. Journal of Traditional and Complementary Medicine 2(2): 145-153.
2012 Chen, I.S., Chen, Y.C., Chou, C.H., Chuang, R.F., Sheen, L.Y., and Chiu, C.H. 2012. Hepatoprotection of silymarin against thioacetamide-induced chronic liver fibrosis. Journal of the Science of Food and Agriculture 92(7): 1441-1447. (SCI)
2012 Wang, H.C., Hsieh, S.C., Yang, J.H., Lin, S.Y., and Sheen, L.Y.* 2012. Diallyl trisulfide induces apoptosis of human basal cell carcinoma cells via endoplasmic reticulum stress and the mitochondrial pathway. Nutrition and Cancer 64(5): 770-780. (SCI)
2012 Chen, P.J., Pang, V.F., Jeng, Y.M. Chen, T.J., Hu, F.C., Chi, W.T., Chou, H.Y., Chiu, H.C., Lee, Y.C., and Sheen, L.Y.* 2012. Establishment of a standardized animal model of chronic hepatotoxicity using acetaminophen-induced hepatotoxicity in the evaluation of hepatoprotective effects of health food. Journal of Food and Drug Analysis 20(1): 43-49. (SCI)
2011 Wang, Y.W., Lii, C.K., Sheen, L.Y., and Liu, C.T. 2011. The effect of garlic oil on insulin secretion in HIT-T15 cells. Nutritional Science Journal 36 (4): 29-39.
2011 Chao, D.P., Tyan, C.C., Chen, J.J., Hsieh, C.L., and Sheen, L.Y.* 2011. Effect of hot-attribute aged ginger tea on Chinese medical pulse condition of healthy young humans. Journal of Traditional and Complementary Medicine 1(1): 69-75.
2011 Chen, P.J. and Sheen, L.Y.* 2011. Gastrodiae Rhizoma (天麻 tiān má): a review of biological activity and antidepressant mechanisms. Journal of Traditional and Complementary Medicine 1(1): 31-40.
2011 Chao, D.P., Chen, J.J., Huang, S.Y., Tyan C.C., Hsieh C.L., and Sheen, L.Y.* 2011. Effects of hot and cold foods on signals of heart rate variability and nail fold microcirculation of healthy young humans: a pilot study. Chinese Journal of Physiology 54 (3): 145-152. (SCI)
2011 Su, Z.Y., Tung, Y.C., AnchorAnchorHwang, L.S., and Sheen, L.Y.* 2011. Blazeispirol A from Agaricus blazei fermentation product induces cell death in human hepatoma Hep 3B cells through caspase-dependent and caspase-independent pathways. Journal of the Agricultural and Food Chemistry 59 (9): 5109-5116. (SCI)
2011 Chen, P.J., Liang, K.C., Lin, H.C., Hsieh, C.L., Su, K.P., Hung M.C., and Sheen, L.Y.* 2011. Gastrodia elata Bl. Attenuated learning deficits induced by forced-swimming stress in the inhibitory avoidance task and Morris water maze. Journal of Medicinal Food 14 (6): 610-617. (SCI)
2010 Chi, H.M., Chou, S.T., Lin, S.C., Su, Z.Y., and Sheen, L.Y.* 2010. Protective effects of water extract of clam on normal and CCl4-induced damage in primary rat hepatocytes. The American Journal of Chinese Medicine 38 (6): 1193-1205. (SCI)
2010 Liao, C.L., Huang H.Y., Sheen, L.Y., and Chou, C.C. 2010. Anti-inflammatory activity of soymilk and fermented soymilk prepared with lactic acid bacterium and bifidobacterium. Journal of Food and Drug Analysis 18 (3): 202-207. (SCI)
2010 Wang, H.C., Yang, J.H., Hsieh S.C., and Sheen, L.Y.* 2010. Allyl sulfides inhibit cell growth of skin cancer cells through induction of DNA damage mediated G2/M arrest and apoptosis. Journal of the Agricultural and Food Chemistry 58(11): 7096-103. (SCI)
2010 Lin, Y.W., Pan, J.H., Sheen, L.Y., Liu, R.H., Kuo, Y.H., and Chiang, B.H. 2010. The 4-acetylantroquinonol B isolated from mycelium of Antrodia cinnamomea inhibits proliferation of hepatoma cells. Journal of the Science of Food and Agriculture 90 (10): 1739-1744. (SCI)
2010 Lin, S.Y., Sheen, L.Y., Chiang, B.H., Yang, J.S., Pan, J.H., Chang, Y.H., Hsu, Y.M., Chiang, J.H., Lu, C.C., Wu, C.L., and Chung, J.G. 2010. Dietary effect of Antrodia camphorate extracts on immune responses in WEHI-3 leukemia BALB/c mice . Nutrition and Cancer 62 (5): 593-600. (SCI)
2010 Wang, Y.J., Sheen, L.Y., and Chou, C.C. 2010. Storage effects on the content of anthocyanin, mutagnicity and antimutagenicity of black soybean koji. International Journal of Food Science and Technology 43 (4): 702-707. (SCI)
2010 Lei, Y.P., Liu, C.T., Sheen, L.Y., Chen H.W., and Lii, C.K. 2010. Diallyl disulfide and diallyl trisulfide protect endothelial nitric oxide synthase against damage by oxidized low-density lipoprotein. Molecular Nutrition and Food Research 54 (suppl 1): S42-52. (SCI)
2010 Huang, R.Y., Wang, Y.J., Sheen, L.Y., and Chou, C.C. 2010. Storage temperature and packaging condition affect the total phenolic content and antioxidant activity of black soybeans and koji. International Journal of Food Science and Technology 45 (3): 437-443. (SCI)
2009 Chen, P.J., Hsieh, C.L., Su, K.P., Hou, Y.C., Jiang, X.M., Lin, I.H., and Sheen, L.Y.* 2009. Rhizomes of Gastrodia elata Bl. possess antidepressant-like effect via monoamine modulation in subchronic animal model. The American Journal of Chinese Medicine 37 (6): 1113-1124. (SCI)
2009 Chen, Y.K., Kuo, Y.H., Chiang, B.H., Lo, J.M., and Sheen, L.Y.* 2009. Cytotoxic activities of 9,11-dehydroergosterol peroxide and ergosterol peroxide from the fermentation mycelia of Ganoderma lucidum cultivated in the medium containing leguminous plants on Hep 3B cells. Journal of the Agricultural and Food Chemistry 57 (13): 5713-5719. (SCI)
2009 Liu, C.T., Su, H.M., Lii, C.K., and Sheen, L.Y. 2009. Effect of supplementation with garlic oil on activity of Th1 and Th2 lymphocytes from rats. Planta Medica 75 (3): 205-210. (SCI)
2008 Pan, J.H., Chen, Y.S., Sheen, L.Y., and Chiang, B.H. 2008. Large-scale submerged fermentation of Antrodia cinnamomea for anti-hepatoma activity. Journal of the Science of Food and Agriculture 88: 2223-2230. (SCI)
2008 Su, Z.Y., Hwang, L.S., Kuo, Y.H., Shu, C.H., and Sheen, L.Y.* 2008. Black soybean promotes the formation of active components with antihepatoma activity in the fermentation product of Agaricus blazei. Journal of the Agricultural and Food Chemistry 56 (20): 9447-9454. (SCI)
2008 Lei, Y.P., Chen, H.W., Sheen, L.Y., and Lii, C.K. 2008. Diallyl disulfide and diallyl trisulfide suppress oxidized LDL-induced vascular cell adhesion molecule and E-selectin expression through protein kinase A- and B-dependent signaling pathways. The Journal of Nutrition 138 (6): 996-1003. (SCI)
2008 Chen, Y.S., Pan, J.H., Chiang, B.H., and Sheen, L.Y.* 2008. Ethanolic extracts of Antrodia cinnamomea mycelia fermented at varied times and scales have differential effects on hepatoma cells and normal primary hepatocytes. Journal of Food Science 73 (7): H179-H185. (SCI)
2008 Chen, P.J., Hsieh, C.L., Su, K.P., Hou, Y.C., Jiang, X.M., Lin, I.H., and Sheen, L.Y.* 2008. The antidepressant effect of Gastrodia elata Bl. on the forced-swimming test in rats. The American Journal of Chinese Medicine 36 (1): 95-106. (SCI)
2007 Liu, C.T., Sheen, L.Y., and Lii, C.K. 2007. Does garlic have a role as antidiabetic agent? Molecular Nutrition and Food Research 51 (11): 1353-1364. (SCI)
2007 Tsai, C.W., Chen, H.W., Yang, J.J., Sheen, L.Y., and Lii, C.K. 2007. Diallyl disulfide and diallyl trisulfide up-regulate the expression of the π class of glutathione S-transferase via an AP-1-dependent pathway. Journal of the Agricultural and Food Chemistry 55 (3): 1019-1026. (SCI)
2006 Liu, K.L., Chen, H.W., Wan, R.Y., Lei, Y.P., Sheen, L.Y., and Lii, C.K. 2006. DATS reduces LPS-induced iNOS expression, NO production, oxidative stress and NF-κB activation in RAW  264.7 macrophages. Journal of the Agricultural and Food Chemistry 54 (9): 3472-3478. (SCI)
2006 Lin, W.C., Liao, Y.C., Liau, M.C., and Sheen, L.Y.* 2006. Inhibitory effect of CDA-II, a urinary preparation, on alflatoxin B1-induced DNA damage in primary rat hepatocytes. Food and Chemical Toxicology 44 (4): 546-551. (SCI)
2005 Tsai, C.W., Yang, J.J., Chen, H.W., Sheen, L.Y., and Lii, C.K. 2005. Garlic organosulfur compounds up-regulate the expression of the π class of glutathione S-transferase in rat primary hepatocytes. Journal of Nutrition 135 (11): 2560-2565. (SCI)
2005 Liu, C.T., Hse, H., Lii, C.K., Chen, P.S., and Sheen, L.Y. 2005. Effect of garlic oil and diallyl trisulfide on glycemic control in streptozotocin-induced diabetic rats. European Journal of Pharmacology 516 (2): 165-173. (SCI)
2004 Yang, J.H., Chou, C.C., Cheng, Y.W., Sheen, L.Y., Chou, M.C., Yu, H.S., Wei, Y.H., and Chung, J.G. 2004. Effects of glycolic acid on the induction of apoptosis via caspase-3 activation in human leukemia cell line (HL-60). Food and Chemical Toxicology 42 (11): 1777-1784. (SCI)
2004 Wu, C.C., Chung, J.G., Tsai, S.J., and Sheen, L.Y.* 2004. Differential effects of allyl sulfides from garlic essential oil on cell cycle regulation in human liver tumor cells. Food and Chemical Toxicology 42 (12): 1937-1947. (SCI)
2004 Wu, C.C., Lii, C.K., Tsai, S.J., and Sheen, L.Y.* 2004. Diallyl trisulfide modulates cell viability and the antioxidation and detoxification systems of rat primary hepatocytes. Journal of Nutrition 134 (4): 724-728. (SCI)
2003 Kao, M.J. and Sheen, L.Y.* 2003. Effects of infrared and low-power laser irradiation on cell viability, glutathione and glutathione-related enzyme activities in primary rat hepatocytes. Journal of Formosa Medicine Association 102 (7): 486-491. (SCI)
2003 Lin, W.C., Liao, Y.C. Liau, M.C., and Sheen, L.Y.* 2003. Effect of CDA-II on cell viability, lipidperoxidation, glutathione concentration and its related enzyme activities in primary rat hepatocytes. The American Journal of Chinese Medicine 31 (3): 415-423. (SCI)
2002 Wu, C.C., Sheen, L.Y., Chen, H.W., Kuo, W.W., Tsai, S.J., and Lii, C.K. 2002. Differential effects of garlic oil and its three major organosulfur components on the hepatic detoxification system in rats. Journal of the Agricultural and Food Chemistry 50: 378-383. (SCI)
2001 Chen, H.W., Yang, J.J., Tsai, C.W., Wu, C.C., Sheen, L.Y., Ou, C.C., and Lii, C.K. 2001. Dietary fat and garlic oil independently regulate hepatic cytochrome P450 2B1 and the placental form of glutathione S-transferase expression in rats. Journal of Nutrition 131: 1438-1443. (SCI)
2001 Sheen, L.Y.*, Wu, C.C., Lii, C.K., and Tsai, S.J. 2001. Effect of diallyl sulfide and diallyl disulfide, the active principles of garlic, on the alflatoxin B1-induced DNA damage in primary rat hepatocytes. Toxicology Letters 122 (1): 45-52. (SCI)
2001 Chen, C.C., Wang, H.J., Shih, H.C., Sheen, L.Y., Chang, C.T., Chen, R.H., and Wang, T.Y. 2001. Comparison the metabolic effects of metformin and troglitazone on fructose-induced insulin resistance in male Sprague-Dawley rats. Journal of Formosa Medicine 100 (3): 176-180. (SCI)
2001 Wu, C.C., Sheen, L.Y., Chen, H.W., Tsai, S.J., and Lii, C.K. 2001. Effect of organosulfur compounds from garlic oil on the antioxidation system in rat liver and red blood cells. Food and Chemical Toxicology 39 (6): 563-569. (SCI)
1999 Sheen, L.Y., Chen, H.W., Kung, Y.L., Liu, C.T., and Lii, C.K. 1999. Effects of garlic oil and its organosulfur compounds on the activities of hepatic drug-metabolizing and antioxidant enzymes  in rats fed high- and low-fat diets. Nutrition and Cancer 35 (2): 160-166. (SCI)
1999 Sheen, L.Y.*, Wu, C.C., Lii, C.K., and Tsai, S.J. 1999. Metabolites of diallyl disulfide and diallyl sulfide in primary rat hepatocytes. Food and Chemical Toxicology 37 (12): 1139-1146. (SCI)
1999 Sheen, L.Y.*, Sheu, S.F., Tsai, S.J., Meng, R.H.C., and Lii, C.K. 1999. Effect of garlic active principle – diallyl disulfide – on cell viability, lipid peroxidation, glutathione concentration and its related enzyme actives in primary rat hepatocytes. The American Journal of Chinese Medicine 27 (1): 95-105. (SCI)
1998 林淑媛、许靖宜、陈宇嘉、张锦文、沈立言*。1998。医院营养师对医院营养部伙食外包厂商考考量及品质之看法。中国医药学院杂志 7 (4): 127-134.
1998 许靖宜、林淑媛、陈宇嘉、张锦文、沈立言*。1998。医院营养师对于伙食外包可行性之研究。中国医药学院杂志 7 (3): 173-182.
1998 Liu, C.T., Chen, H.W., Sheen, L.Y., Kung, Y.L., Chen, P.C.H., and Lii, C.K. 1998. Effect of garlic oil on hepatic arachidonic acid content and immune response in rats. Journal of the Agricultural and Food Chemistry 46: 4642-4647. (SCI)
1997 Chen, H.W., Lii, C.K., Wu, M.H., Ou, C.C., and Sheen, L.Y. 1997. Amount and type of dietary lipid modulate rat hepatic cytochrome P-450 activity. Nutrition and Cancer 29: 174-180. (SCI)
1997 Lin, C.W., Lin, T.H., Sheen, L.Y., Chung, C.H., and Cheng, K.S. 1997. Diallyl sulfide as a potent inducer on the granulocytic/ macrophagic differentiation of K562 human leukemic cells. Med. J. CMCH 2: 149-154.
1997 叶佳圣、沈立言、李宗贵、蔡顺仁。1997。补骨脂水萃取物及补骨脂酚对大白鼠初代肝细胞之抗氧化保护作用。中华民国营养学会杂志22 (3): 303-324.
1997 Wang, S.T., Chen, H.W., Sheen, L.Y., and Lii, C.K. 1997. Methionine and cysteine affect glutathione level, glutathione-related enzyme activities and the expression of glutathione S-transferase isozymes in rat hepatocytes. The Journal of Nutrition 127: 2135-2141. (SCI)
1997 Chen, H.W., Ko, J.J., Lii, C.K., Ou, C.C., and Sheen, L.Y. 1997. Corn oil enhances gamma-glutamyl transpeptidase-positive foci development in the presence of phenobarbital during hepatocarcinogenesis in rats. Nutrition and Cancer 28 (3): 252-257. (SCI)
1997 叶佳圣、沈立言、蔡顺仁。1997。补骨脂酚对大白鼠初代肝细胞之抗氧化生理活性之影响。食品科学24 (3): 295-307.
1997 沈立言*、吴志忠。1997。大蒜素于45oC下在不同油脂中之变化。中华民国营养学会杂志22 (1): 89-102.
1996 Sheen, L.Y.*, Lii, C.K., Sheu, S.F., Meng, R.H.C., and Tsai, S.J. 1996. Effect of the active principle of garlic – diallyl sulfide – on the cell viability, detoxification capability and antioxidation system of primary rat hepatocytes. Food and Chemical Toxicology 34: 971- 978. (SCI)
1996 Lii, C.K., Wang, S.T., Chen, H.W., and Sheen, L.Y. 1996. Glutathione and glutathione-related enzyme activities of male and female rat hepatocytes under various culture conditions. Archives of Toxicology 70: 822-829. (SCI)
1995 沈立言*、吴志忠、蔡顺仁。1995。大蒜精油在不同油脂中之安定性。中华民国营养学会杂志20 (4): 381-392.
1994 沈立言*、吕英震、康志强、林淑媛、蔡顺仁。1994。大蒜保健食品中活性成分之定性及定量分析。中华民国营养学会杂志 19 (4): 395-406.
1994 Lin, S.Y., Sheen, L.Y., and Tsai, S.J. 1994. Effect of microwave-heating on retention and composition of basil oil. Food Science 21 (1): 75-82.
1992 林淑媛、沈立言、蔡顺仁。1992。蒜、薑精油微胶囊在储藏后之香味变化。中国农业化学会志30 (4): 544-552.
1992 沈立言、林淑媛、蔡顺仁。1992。利用相分离法制备精油微胶囊及其性质之探讨。中国农业化学会志 30 (3): 307-320.
1992 沈立言、林淑媛、蔡顺仁。1992。不同精油添加量对于喷雾干燥精油微胶囊品质之影响。食品科学 19 (2): 217-229.
1992 沈立言、林淑媛、蔡顺仁。1992。以气相层析仪嗅闻法进行蒜及薑精油挥发性成分香气之评估。中国农业化学会志 30 (1): 14-24.
1991 沈立言、林淑媛、蔡顺仁。1991。不同精油含量之罗勒、蒜、薑精油微胶囊之制备及其精油成分在喷雾干燥过程中之变化。食品科学18 (4): 344-355.
1991 沈立言、蔡顺仁。1991。薑、罗勒、蒜喷雾干燥精油胶囊之制备及其性质之研究。中国农业化学会志 29 (2): 226-237.
1991 Sheen, L.Y., Tsai Ou, Y.H., and Tsai, S.J. 1991. Flavor characteristic compounds found in the essential oil of Ocimum basilicum L. with sensory evaluation and statisticalanalysis. Journal of the Agricultural and Food Chemistry 39: 939-943. (SCI)
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2023 Wang, Y. F., Huang, H. S., Panyod, S., Chu, C.Y., Lai, H.M., Wu, M. S., Sheen. L.Y. * 2023. Investigation of skin-protective and immunomodulatory activities of mung bean skin water extract in pruritus mice model. International Conference for Journal of Traditional and Complementary Medicine (ICJTCM 2023). Nov 1-3, Taipei, Taiwan.
2023 Pan, Y.C., Hsu, L.A., Lu, K.H., Huang, Y.J., Sheen, L.Y.* 2023. Predictive models for the growth kinetics of uropathogenic Escherichia coli in sous-vide processed chicken breast. International Association of Food Protection Annual Meeting 2023 (IAFP 2023). July 19, Toronto, Ontario, Canada.
2023 Choi, H. H. T., Sheen, L.Y.* 2023. Metabolomic investigation on the anti-depressant mechanisms of Gastrodia elata Blume. International Symposium on Food and Health for Long Covid. Mar 10, Taipei, Taiwan.
2023 Huang, S.Y., Panyod, S., Wu, W.K., Lo, Y.L., Wu, M.S., Sheen, L.Y.* 2023. Investigation of the preventive effect of Akkermansia muciniphila strain NTUH_Amu03 on GAN diet-induced NASH in mice model through modulating the gut-liver axis. International Symposium on Food and Health for Long Covid. Mar 10, Taipei, Taiwan.
2022 Panyod, S., Hsieh, Y.C. Wu, W.K., Tseng, Y.J., Peng, S.Y., Chen, R.A., Huang, H.S., Wu, M.S. and Sheen, L.Y.* 2022. Ginger essential oil prevents the progression of NASH through blockading NLRP3 inflammasome and remodeling gut microbiota-LPS- TLR4 pathway in palm oil-containing high-fat diet combination with LPS-induced endotoxemia and gut dysbiosis mice model. The 21TH International congress of international society for enthopharmacology (ISE 2022) May 28-31, Taichung, Taiwan.
2022 Peng, S.Y., Panyod, S., Wu, W.K., Hsieh, Y.C., Tseng, Y.J., Chen, R.A., Huang, H.S., Wu, M.S. and Sheen, L.Y.* 2022. Ginger essential oil ameliorates atherosclerosis through gut microbiota and trimethylamine-N-oxide modulation in L-carnitine and GAN diet ApoE-/- mice model. The 21TH International congress of international society for enthopharmacology (ISE 2022) May 28-31, Taichung, Taiwan.
2021 Hung, T.H., Chen, C.H., Liao, S.Y., Hung T.M., Sheen, L.Y.* and Cheng, C.P. 2021. Screening of xanthine oxidase inhibitors in Phyllanthus emblica fruits using ultrafiltration LC‐MS combined with enzyme channel blocking. The 36TH Symposium on Natural Products & Symposium on Traditional Chinese Medicine and Pharmacy 2021, Kaohsiung, Taiwan.
2021 Chou T.W., Huang, H.S., Panyod, S. and Sheen, L.Y.* 2021. The antidepressant effects of Korean red ginseng water extract in unpredictable chronic mild stress. The 11TH Mind- Body Interface International Symposium PNIRSAsia-Pacific Symposium 2021, Taichung, Taiwan.
2021 Tsai, H.C., Huang, H.S., Panyod, S. and Sheen, L.Y.* 2021. The anti-obesity and anti- depressant effects evaluation of Korean red ginseng extract in high-fat diet with an unpredictable chronic mild stress-induced obesity and depression mice model. The 11TH Mind-Body Interface International Symposium PNIRSAsia-Pacific Symposium 2021, Taichung, Taiwan.
2020 Hsin-Yu Wu, Huai-Syuan Huang, Wan-Ting Chang, Yu-En Lin, Yun-Ju Huang, Kuan-Hung Lu, Yun-Sheng Lu, Mei-Hsing Chen*, Lee-Yan Sheen*。2020。The antidepressive and anxiolytic effects of formula consisted of Poria cocos and Cordyceps militaris waster medium extract in unpredictable chronic mild stress animal model
2020 Hui-Ping Lin, Huai-Syuan Huang, Min-Syuan Cai, Kuan-Hung Lu, Yu-En Lin, Yun-Ju Huang, Yun-Sheng Lu, Mei-Hsing Chen*, Lee-Yan Sheen*。2020.The antidepressant-like effects of liquid dietary supplement of Cordyceps militaris and Armillaria mellea formula in unpredictable chronic stress animal model。Mind-Body Interface (MBI) International Symposium
2020 Huai-Syuan Huang, Yu-En Lin, Suraphan Panyod, Lee-Yan Sheen*。2020。Investigation of Gastrodia elata Blume Water Extracts in Unpredictable Chronic Mild Stress (UCMS) induced Depression-Like Behavior and Cognitive Impairment ApoE-/- Mice Model。Taiwan Society for Neuroscience
2020 Ying-Cheng Lin, Lee-Yan Sheen*。2020。Garlic Essential Oil Ameliorates Cardiovascular Disease through Gut Microbiota and Its Metabolites in L-Carnitine-Induced apoE-/- Mice。Agricultural Chemical Society of Taiwan
2020 Min-Shiuan Tsai, Lee-Yan Sheen*。2020。Anti-depressant effect of garlic essential oil through reducing peripheral and brain inflammation in chronic stress animal model。Agricultural Chemical Society of Taiwan
2019 Lin, Y.E., Sheen, L.Y.* and Chien, C.T. 2019. Mechanisms of Gastrodia elata Blume in preventing Lrrk2-G2019S induced-dopaminergic neuron degeneration in Drosophila model of Parkinson’s disease. Institute of Molecular Biology Retreat 2019, Hsinchu, Taiwan.
2019 Chen, P.C., Wu, W.K., Suraphan, P., Wu, M.S. and Sheen, L.Y.* 2019. Allicin ameliorates the process formation of atherosclerosis through modulation of gut microbiota. 18th Meeting of Consortium for Globalization of Chinese Medicine (CGCM 2019), Shanghai, China.
2019 Chai, H.E., Lu, K.H., Huang, T.P., Cheng, C.L., Huang, L., Hwang, C.A., Sheen, S. and Sheen, L.Y.* 2019. Microbiological risk assessment of Staphylococcus aureus in ready-to-eat lettuce in Taiwan. International Association of Food Protection 2019 Annual Meeting (IAFP 2019), Louisville, Kentucky, USA.
2019 Choong, C.L.X., Lin, Y.E., Lu, K.H., Panyod, S., Wu, W.K., Huang, Y.R., Huang, H.S., Sheen, L.Y.* 2019. Water extract of Gastrodia elata Blume may ameliorate subchronic and mild social defeat stress-induced behavior through gut-brain axis in mice. NUTRITION 2019, Annual Nutrition Science Meeting, American Society for Nutrition(ASN), Baltimore, USA.
2019 Chen, P.C., Wu W.K., Panyod, S, Wu M.S., Sheen L.Y.* 2019. Cardiovascular disease protective effect of allicin through gut microbiota modulation. NUTRITION 2019, Annual Nutrition Science Meeting, American Society for Nutrition (ASN), Baltimore, USA.
2019 Chuang, S., Sheen, S.*, Sommers, C., Sheen, L.Y.* 2019. Modeling the inactivation of Escherichia coli O157:H7, uropathogenic E. coli and Salmonella in ground chicken meat subject to hydrostatic pressure, allyl isothiocyanate and trans-cinnamaldehyde stresses. IFT19 Annual Meeting & Food Expo., New Orleans, LA, USA.
2019 Chang, C.T., Wu, W.K., Wada, N., Panyod, S., Liu, P.Y., Chen, R.A., Tang, S.L., Sheen, L.Y.* 2019. Common dietary emulsifiers altered the gut microbiota composition but did not induce colitis and metabolic syndrome. IFT19 Annual Meeting & Food Expo., New Orleans, LA, USA.
2018 Ou, G.L., Lu, K.H., Chang, H.P., Sheen, L.Y.* 2018. Safety evaluation of the water extract of Gastrodia elata Blume. 17th Meeting of Consortium for Globalization of Chinese Medicine, Kuching, Malaysia.
2018 Chang, C.T., Wu, W.K., Chen, C.C., Panyod, S., Chen, R.A., Sheen, L.Y.*, Wu, M.S. 2018. Comparison fecal DNA isolation kits and extraction protocol on the microbial communities in human feces. China Gut Festival, Beijing, China.
2018 Chen, P.C., Wu, W.K., Chen, C.C., Panyod, S., Chen, R.A., Sheen, L.Y.*, Wu, M.S. 2018. Fecal microbiota transplant of TMAO producer induced the increased of plasma TMAO in germ-free mice supplemented with carnitine. China Gut Festival, Beijing, China.
2018 Chen, R.A., Wu, W.K., Panyod, S., Wu, M.S., Chen, C.C., Hsueh, P.R., Sheen, L.Y.* 2018. The impact of an antibiotic residues tylosin in food on the antibiotic resistant gene of the gut microbiota. China Gut Festival, Beijing, China.
2018 Chong, K.V., Panyod, S., Wu, W.K., Chen, R.A., Wu, M.S., Sheen, L.Y.* 2018. Comparison Lieber-DeCarli control liquid diet and ethanol liquid diet on the composition of cecum and feces microbiota in C57BL/6 mice. China Gut Festival, Beijing, China.
2018 Panyod, S., Wu, W.K., Chen, R.A., Wu, M.S, Sheen, L.Y.* 2018. The influence of allicin on gut microbiota composition in C57BL/6 mice. China Gut Festival, Beijing, China.
2018 Yang, Y.T., Wu, W.K., Chen, C.C., Panyod, S., Chen, R.A., Sheen, L.Y.*, Wu, M.S. 2018. Culture the human gut microbiota by using gut microbiota medium in a microaerobic condition. China Gut Festival, Beijing, China.
2018 Chai, H.E., Lu, K.H., Huang, T.P., Cheng, C.L., Huang, L., Hwang, C.A., Sheen, S., Sheen, L.Y.* 2018. Modeling the effect of temperature on the growth of Staphylococcus aureus in fresh-cut lettuce. the International Association for Food Protection 2018 Annual Meeting (IAFP 2018), Salt Lake City, Utah, USA.
2018 Chai, H.E., Lu, K.H., Huang, T.P., Sheen, L.Y.* 2018. Preliminary study of the temperature effect on Staphylococcal enterotoxins production in leafy salad, a popular ready-to-eat food in Taiwan. International Conference on Functional Food for Improving Sarcopenia, Cachexia and Frailty, Taipei, Taiwan.
2018 Huang, H.S., Lin, S.H., Sheen, L.Y.* 2018. Antidepressant-like effects of water extract of coffee beans with different roasting degrees in rats exposed to unpredictable chronic mild stress via modulation of antioxidant pathway. International Conference on Functional Food for improving Sarcopenia, Cachexia and Frailty, Taipei, Taiwan.
2018 Chai, H.E., Lu, H.H., Huang, T.P., Cheng, C.L., Huang, L., Hwang, C.A., Sheen, S., Sheen, L.Y.* 2018. Modeling the effect of temperature on the growth of Staphylococcus aureus in fresh-cut lettuce. International Association for Food Protection Annual Meeting, Salt Lake City, Utah, USA.
2017 Lu, K.H., Weng, C.Y., Chen, W.C., Sheen, L.Y.* 2017. Ginseng essence, a medicinal and edible herbal formulation, ameliorates carbon tetrachloride-induced oxidative stress and liver injury in rats. Journal of Ginseng Research, 41(3): 316-325.
2017 Wang, H.C., Chu, Y.L., Hsieh, S.C., Sheen, L.Y.* 2017, Jun. Diallyl trisulfide inhibits cell migration and invasion of human melanoma A375 cells via inhibiting intergrin/facal adhision kinase pathway. Environmental Toxicology, 32(11): 2352-2359
2016 Hsu, W.F., Sheen, L.Y., Lin, H.J., Chang, H.H. 2016. A review of western and traditional Chinese medical approaches to managing nonalcoholic fatty liver disease. Evidence-Based Complementary and Alternative Medicine, 2016:6491420. Epub 2016 Oct 31.
2016 Chien, S.Y., Sheen, S.*, Sommers, C., Sheen, L.Y. 2016. Modeling the inactivation of Escherichia coli O157:H7 and uropathogenic E. coli in ground beef by high pressure processing and citral. Food Control, 73: 672-680.
2016 Panyod, S., Wu, W.K., Ho, C.T., Lu, K.H., Liu, C.T., Chu, Y.L., Lai, Y.S., Chen, W.C., Lin, Y.E., Lin, S.H., Sheen, L.Y.* 2016. Diet supplementation with allicin protects against alcoholic fatty liver disease in mice by improving anti-inflammation and antioxidative functions. Journal of Agricultural and Food Chemistry, 64(38): 7104-7113.
2016 Huang, W.F., Hong, T.W., Wang, Y.J., Chen, K.C., Pei, J.C., Chuang, T.Y., Lai, W.S., Tsai, S.H., Chu, R., Chen, W.C., Sheen, L.Y., Takahasi, S., Ding, S.T., Shen, T.L. 2016. Ophiocordyceps formosana improves hyperglycemia and depression-like behavior in an STZ-induced diabetic mouse model. BMC Complementary and Alternative Medicine, 16(1): 310.
2016 Chien, S.Y., Sheen, S.*, Sommers, C.H., Sheen, L.Y. 2016. Modeling the inactivation of intestinal pathogenic Escherichia coli O157: H7 and uropathogenic E. coli in ground chicken by high pressure processing and thymol. Frontiers in Microbiology, 7(920): 1-11.
2016 Lin, Y.E., Lin, S.H., Chen, W.C., Ho, C.T., Lai, Y.S., Panyod, S., and Sheen, L.Y.* 2016. Antidepressant-like effects of water extract of Gastrodia elata Blume in rats exposed to unpredictable chronic mild stress via modulation of monoamine regulatory pathways. Journal of Ethnopharmacology, 187: 57-65.
2016 Lu, K.H., Pan, Y.C., Sheen, L.Y.* 2016. Reflection on food safety incidents in Taiwan: From crisis response to risk management. Journal of Chinese Dietary Culture (in Chinese), 12(1): 245-271.
2016 Lai, Y.S., Lee, W.C., Lin, Y.E., Ho, C.T., Lu, K.H., Lin, S.H., Panyod, S., Chu, Y.L., Sheen, L.Y.* 2016. Ginger essential oil ameliorates hepatic injury and lipid accumulation in high fat diet-induced nonalcoholic fatty liver disease. Journal of Agricultural and Food Chemistry, 64(10): 2062-2071.
2016 Chen, W.C., Lai, Y.S., Lin, S.H., Lu, K.H., Panyod, S., Ho, C.T., Sheen, L.Y.* 2016. Anti-depressant effects of Gastrodia elata Blume and its compounds, gastrodin and 4-hydroxybenzyl alcohol, involve the monoaminergic system and neuronal cytoskeletal remodeling processes. Journal of Ethnopharmacology, 182: 190-199.
2015 Lin, S.H, Chou, M.L., Chen, W.C., Lai, Y.S., Lu, K.H., Hao, C.W., Chu, Y.L., Sheen, L.Y.* 2015. Antidepressant-like activity of the water extract of Melissa officinalis L. in forced swimming test via regulation of the serotonergic neurotransmitter. Journal of Ethnopharmacology, 175: 266-272.
2015 Lai, Y.S., Chen, W.C., Kuo, T.C., Ho, C.T., Kuo, C.H., Tseng, Y, Lu, K.H., Lin, S.H. Panyod, S., Sheen, L.Y.* 2015. Mass spectrometry-based serum metabolomics of a C57BL/6J mouse model of high-fat diet induced nonalcoholic fatty liver disease development. Journal of Agricultural and Food Chemistry, 63(35): 7873-7884.
2015 Wu, W.K., Panyod, S., Ho, C.T., Kuo, C.H., Wu, M.S., Sheen, L.Y.* 2015. Dietary allicin reduces transformation of L-carnitine to TMAO through impact on gut microbiota. Journal of Functional Foods, 15: 408-417.
2015 Huang, L.Y., Chu, Y.L., Ho, C.T., Chung, J.G., Lai C.I., Su, Y.C., Kuo, Y.H., Sheen, L.Y.* 2015. Antcin K, an active triterpenoid from the fruiting bodies of basswood cultivated Antrodia cinnamomea, inhibits metastasis via suppression of integrin-mediated adhesion, migration, and invasion in human hepatoma cells. Journal of Agricultural and Food Chemistry, 63(18): 4561-4569.
2015 Chen, W.C., Lai, Y.S., Lu, K.H., Lin, S.H., Liao, L.Y., Ho, C.T., Sheen, L.Y.* 2015. Method development and validation for the HPLC assay of gastrodin in water extracts from different sources of Gastrodia elata Blume. Journal of Food and Drug Analysis, 23(4): 803-810.
2015 Cheng, B.H., Sheen, L.Y., Chang, S.T. 2015. Evaluation of anxiolytic potency of essential oil and S-(+)-linalool from Cinnamomum osmophloeum ct. linalool leaves in mice. Journal of Traditional and Complementary Medicine, 5(1): 27-34.
2015 Lu, K.H. and Sheen, L.Y.* 2015. How do consumers protect themselves from the impact of food safety incidents. Judicial Aspiration (in Chinese), 113: 25-29.
2014 Chen, P.B., Wang, H.C., Liu, Y.W., Lin, S.H., Chou, H.N., Sheen L.Y.* 2014. Immunomodulatory activities of polysaccharides from Chlorella pyrenoidosa in a mouse model of Parkinson’s disease. Journal of Functional Foods, 11: 103-113.
2014 Lin, S.H., Chen, W.C, Lu, K.H., Chen, P.J., Hsieh, S.C. Pan, T.M., Chen, S.T., Sheen, L.Y.* 2014. Down-regulation of Slit-Robo pathway mediating neuronal cytoskeletal remodeling processes facilitates the antidepressive-like activity of Gastrodia elata Blume. Journal of Agricultural and Food Chemistry, 62(43): 10493-10503.
2014 Chang, H.P., Sheen L.Y., Lei, Y.P. 2014. The protective role of carotenoids and polyphenols in patients with head and neck cancer. Journal of the Chinese Medical Association, 78(2): 89-95.
2014 Lai, Y.S., Chen, W.C., Ho, C.T., Lu, K.H., Lin, S.H., Tseng, H.C., Sheen, L.Y.* 2014. Garlic essential oil protects against obesity-triggered nonalcoholic fatty liver disease through modulation of lipid metabolism and oxidative stress. Journal of Agricultural and Food Chemistry, 62(25): 5897-5906.
2014 Lo, W.Y., Sheen, L.Y., Lo, Y.C., Hsieh, S.C. 2014. The effects of blackcurrant on anti-inflammation and prevention of allergic respiratory diseases syndrome. Journal of Agricultural Chemistry and Food Science, 52(1): 25-30.
2014 Lu, K.H., Tseng, H.C., Liu, C.T., Huang, C.J., Chyuanc, J.H., Sheen, L.Y.* 2014. Wild bitter gourd protects against alcoholic fatty liver in mice by attenuating oxidative stress and inflammatory responses. Food and Function, 5(5): 1027-1037.
2013 Liu, Y.T., Lo, Y.C., Hsieh, S.C., Sheen, L.Y.* 2013. The antioxidant activity of blackcurrant and its effects on Parkinson's disease and Alzheimer's disease. Nutrition Society of Taiwan (in Chinese), 38(4): 120-131.
2013 Chu, Y.L., Chimeddulam, D., Sheen, L.Y.*, Wu, K.Y. 2013. Probabilistic risk assessment of exposure to leucomalachite green residues from fish products. Food and Chemical Toxicology, 62: 770-776.
2013 Liu, C.T., Raghu, R., Lin, S.H., Wang, S.Y., Kuo, C.H., Tseng, Y.J., Sheen, L.Y.* 2013. Metabolomics of ginger essential oil against alcoholic fatty liver in mice. Journal of Agricultural and Food Chemistry, 61(46): 11231-11240.
2013 Chu, Y.L., Ho, C.T., Chung, J.G., Rajasekaran R., Lo Y.C., Sheen, L.Y.* 2013. Allicin induces anti-human liver cancer cells through the p53 gene modulating apoptosis and atophagy. Journal of Agricultural and Food Chemistry, 61: 9839-9848.
2013 Chen, S.F., Hu, T.M., Lan, T.H., Chiu, H.J., Sheen, L.Y.*, Loh, E.W. 2013. Severity of psychosis syndrome and change of metabolic abnormality in chronic schizophrenia patients: Severe negative syndrome may be related to a distinct lipid pathophysiology. European Psychiatry, 29(3): 167-171.
2013 Chu, Y.L., Rajasekaran, R., Lu, K.H., Liu, C.T., Lin, S.H., Lai, Y.S., Chen, W.C., Lin, S.H., Sheen, L.Y.* 2013. Autophagy therapeutic potential of garlic in human cancer therapy. Journal of Traditional and Complementary Medicine, 3(3): 159-162.
2013 Lin, S.H., Chang, H.C., Chen, P.J., Hsieh, C.L., Su, K.P., Sheen, L.Y.* 2013. The antidepressant-like effect of ethanol extract of daylily flowers (金针花 Jīn Zhēn Huā ) in rats. Journal of Traditional and Complementary Medicine, 3(1): 53-61
2012 Raghu R., Liu, C.T., Tsai, M.H., Tang, X., Kalari, K.R., Subramanian, S., and Sheen, L.Y.* 2012. Transcriptome analysis of garlic induced hepatoprotection against alcoholic fatty liver. Journal of the Agricultural and Food Chemistry 60(44): 11104-11119.
2012 Wu, C.C., Chu, Y.L., and Sheen, L.Y.* 2012. Allicin modulates the antioxidation and detoxification capability in primary rat hepatocytes. Journal of Traditional and Complementary Medicine 2(4): 323-330.
2012 Su, Y.C., Liu, C.T., Raghu, R., Kuo, Y.H., and Sheen, L.Y.* 2012. Eburicoic acid, an active triterpenoid from the fruiting bodies of basswood cultivated Antrodia cinnamomea, induces ER stress-mediated autophagy in human hepatoma cells. Journal of Traditional and Complementary Medicine 2(4): 312-322.
2012 Liu, Y.W., Lu, K.H., Ho, C.T., and Sheen, L.Y.* 2012. Protective effects of Antrodia cinnamomea against liver injury. Journal of Traditional and Complementary Medicine 2(4): 284-294.
2012 Wang H.C., Pao, J., Lin, S.Y., and Sheen, L.Y.* 2012. Molecular mechanisms of garlic-derived allyl sulfides in the inhibition of skin cancer progression. Annals of the New York Academy of Sciences 1271(1): 44-52.
2012 Chu, Y.L., Ho, C.T., Chung, J.G., Raghu, R., and Sheen, L.Y.* 2012. Allicin induces p53-mediated autophagy in Hep G2 human liver cancer cells. Journal of the Agricultural and Food Chemistry 60(34): 8363-8371.
2012 Raghu, R., Lu, K.H., and Sheen, L.Y.* 2012. Recent research progress on garlic (大蒜 dà suàn) as a potential anticarcinogenic agent against major digestive cancers. Journal of Traditional and Complementary Medicine 2(3): 192-201.
2012 Lu, K.H., Liu, C.T., Raghu, R., and Sheen, L.Y.* 2012. Therapeutic potential of Chinese herbal medicines in alcoholic liver disease. Journal of Traditional and Complementary Medicine 2(2): 115-122.
2012 Liu, C.T., Hsu, T.W., Chen, K.M., Tan, Y.P., Lii, C.K., and Sheen, L.Y.* 2012. The antidiabetic effect of garlic oil is associated with ameliorated oxidative stress but not ameliorated level of pro-inflammatory cytokines in skeletal muscle of streptozotocin-induced diabetic rats. Journal of Traditional and Complementary Medicine 2(2): 135-144.
2012 Tsai, C.W., Chen, H.W., Sheen, L.Y., and Lii, C.K. 2012. Garlic: Health benefits and actions. BioMedicine 2(1): 17-29.
2012 Tung, Y.C., Su, Z.Y., Kuo, M.L., and Sheen, L.Y.* 2012. Ethanolic extract of Agaricus blazei fermentation product inhibits the growth and invasion of human hepatoma HA22T/VGH and SK-Hep-1 cells. Journal of Traditional and Complementary Medicine 2(2): 145-153.
2012 Chen, I.S., Chen, Y.C., Chou, C.H., Chuang, R.F., Sheen, L.Y., and Chiu, C.H. 2012. Hepatoprotection of silymarin against thioacetamide-induced chronic liver fibrosis. Journal of the Science of Food and Agriculture 92(7): 1441-1447. (SCI)
2012 Wang, H.C., Hsieh, S.C., Yang, J.H., Lin, S.Y., and Sheen, L.Y.* 2012. Diallyl trisulfide induces apoptosis of human basal cell carcinoma cells via endoplasmic reticulum stress and the mitochondrial pathway. Nutrition and Cancer 64(5): 770-780. (SCI)
2012 Chen, P.J., Pang, V.F., Jeng, Y.M. Chen, T.J., Hu, F.C., Chi, W.T., Chou, H.Y., Chiu, H.C., Lee, Y.C., and Sheen, L.Y.* 2012. Establishment of a standardized animal model of chronic hepatotoxicity using acetaminophen-induced hepatotoxicity in the evaluation of hepatoprotective effects of health food. Journal of Food and Drug Analysis 20(1): 43-49. (SCI)
2011 Wang, Y.W., Lii, C.K., Sheen, L.Y., and Liu, C.T. 2011. The effect of garlic oil on insulin secretion in HIT-T15 cells. Nutritional Science Journal 36 (4): 29-39.
2011 Chao, D.P., Tyan, C.C., Chen, J.J., Hsieh, C.L., and Sheen, L.Y.* 2011. Effect of hot-attribute aged ginger tea on Chinese medical pulse condition of healthy young humans. Journal of Traditional and Complementary Medicine 1(1): 69-75.
2011 Chen, P.J. and Sheen, L.Y.* 2011. Gastrodiae Rhizoma (天麻 tiān má): a review of biological activity and antidepressant mechanisms. Journal of Traditional and Complementary Medicine 1(1): 31-40.
2011 Chao, D.P., Chen, J.J., Huang, S.Y., Tyan C.C., Hsieh C.L., and Sheen, L.Y.* 2011. Effects of hot and cold foods on signals of heart rate variability and nail fold microcirculation of healthy young humans: a pilot study. Chinese Journal of Physiology 54 (3): 145-152. (SCI)
2011 Su, Z.Y., Tung, Y.C., Hwang, L.S., and Sheen, L.Y.* 2011. Blazeispirol A from Agaricus blazei fermentation product induces cell death in human hepatoma Hep 3B cells through caspase-dependent and caspase-independent pathways. Journal of the Agricultural and Food Chemistry 59 (9): 5109-5116. (SCI)
2011 Chen, P.J., Liang, K.C., Lin, H.C., Hsieh, C.L., Su, K.P., Hung M.C., and Sheen, L.Y.* 2011. Gastrodia elata Bl. Attenuated learning deficits induced by forced-swimming stress in the inhibitory avoidance task and Morris water maze. Journal of Medicinal Food 14 (6): 610-617. (SCI)
2010 Chi, H.M., Chou, S.T., Lin, S.C., Su, Z.Y., and Sheen, L.Y.* 2010. Protective effects of water extract of clam on normal and CCl4-induced damage in primary rat hepatocytes. The American Journal of Chinese Medicine 38 (6): 1193-1205. (SCI)
2010 Liao, C.L., Huang H.Y., Sheen, L.Y., and Chou, C.C. 2010. Anti-inflammatory activity of soymilk and fermented soymilk prepared with lactic acid bacterium and bifidobacterium. Journal of Food and Drug Analysis 18 (3): 202-207. (SCI)
2010 Wang, H.C., Yang, J.H., Hsieh S.C., and Sheen, L.Y.* 2010. Allyl sulfides inhibit cell growth of skin cancer cells through induction of DNA damage mediated G2/M arrest and apoptosis. Journal of the Agricultural and Food Chemistry 58(11): 7096-103. (SCI)
2010 Lin, Y.W., Pan, J.H., Sheen, L.Y., Liu, R.H., Kuo, Y.H., and Chiang, B.H. 2010. The 4-acetylantroquinonol B isolated from mycelium of Antrodia cinnamomea inhibits proliferation of hepatoma cells. Journal of the Science of Food and Agriculture 90 (10): 1739-1744. (SCI)
2010 Lin, S.Y., Sheen, L.Y., Chiang, B.H., Yang, J.S., Pan, J.H., Chang, Y.H., Hsu, Y.M., Chiang, J.H., Lu, C.C., Wu, C.L., and Chung, J.G. 2010. Dietary effect of Antrodia camphorate extracts on immune responses in WEHI-3 leukemia BALB/c mice . Nutrition and Cancer 62 (5): 593-600. (SCI)
2010 Wang, Y.J., Sheen, L.Y., and Chou, C.C. 2010. Storage effects on the content of anthocyanin, mutagnicity and antimutagenicity of black soybean koji. International Journal of Food Science and Technology 43 (4): 702-707. (SCI)
2010 Lei, Y.P., Liu, C.T., Sheen, L.Y., Chen H.W., and Lii, C.K. 2010. Diallyl disulfide and diallyl trisulfide protect endothelial nitric oxide synthase against damage by oxidized low-density lipoprotein. Molecular Nutrition and Food Research 54 (suppl 1): S42-52. (SCI)
2010 Huang, R.Y., Wang, Y.J., Sheen, L.Y., and Chou, C.C. 2010. Storage temperature and packaging condition affect the total phenolic content and antioxidant activity of black soybeans and koji. International Journal of Food Science and Technology 45 (3): 437-443. (SCI)
2009 Chen, P.J., Hsieh, C.L., Su, K.P., Hou, Y.C., Jiang, X.M., Lin, I.H., and Sheen, L.Y.* 2009. Rhizomes of Gastrodia elata Bl. possess antidepressant-like effect via monoamine modulation in subchronic animal model. The American Journal of Chinese Medicine 37 (6): 1113-1124. (SCI)
2009 Chen, Y.K., Kuo, Y.H., Chiang, B.H., Lo, J.M., and Sheen, L.Y.* 2009. Cytotoxic activities of 9,11-dehydroergosterol peroxide and ergosterol peroxide from the fermentation mycelia of Ganoderma lucidum cultivated in the medium containing leguminous plants on Hep 3B cells. Journal of the Agricultural and Food Chemistry 57 (13): 5713-5719. (SCI)
2009 Liu, C.T., Su, H.M., Lii, C.K., and Sheen, L.Y. 2009. Effect of supplementation with garlic oil on activity of Th1 and Th2 lymphocytes from rats. Planta Medica 75 (3): 205-210. (SCI)
 
 
 
 
  1. 沈立言*。201011-202011。抗忧郁饮品之配方与制程。
  2. 沈立言*主编、李锦枫总校阅。2014。食品与健康。扬智文化公司，台北，台湾。
  3. Su, Z.Y. and Sheen, L.Y.* 2011. An Evidence-based Perspective of Ganoderma Lucidum (Lucid Ganoderma) for Cancer Patients. Chapter 12 in “Evidence-based Anticancer Materia Medica”edited by Cho, W.C.S., p.p. 245-263, DOI: 10.1007/978-94-007-0526-5_12, Springer.
  4. Sheen, L.Y.* and Fuentes, G. 2011. Yin Yang, Five Phase Theory, and the Application of Traditional Chinese Functional Foods, Chapter 1 in “Functional Foods of the East” edited by Shi, J., Ho, C.T. and Shahidi, F., p.p. 1-12, CRC Press.
  5. 沈立言*。2009。Chapter 23糖尿病辅助与替代医学，糖尿病卫教核心教材，p.284~303。中华民国糖尿病卫教学会，台北市。
  6. 潘怀宗、璩大成、程树德、严一峰、李敏西、张珩、冯长风、陈旺全、沈立言、孙安迪。2009。大流感：预防流感关键10堂课。文经社。台北市。
  7. 潘怀宗、张珩、沈立言、璩大成、严一峰、程树德、李敏西、陈旺全、孙安迪。2006。全方位抗流感。文经社。台北市。
  8. 沈立言*、何礼刚、王凤英、顾佑瑞。2004。中医食疗与养生。禾枫书局有限公司。台北市。
  9. 沈立言*、林淑媛、吴裕仁、高千雯、张正芬。2001。美容营养学。华格那企业。台中市。
  10. Ho, C.T., Sheen, L.Y., 1990. Wu, P., Kuo, M.C., Hartman, T.G., and Rosen, R.T.: Glycosidically bound aroma compounds in pineapple and peach. In "Flavor Science and Technology", p.77-80. Y. Bessiere and A.F. Thomas Ed., John Wiley & Sons, Ltd., Chichester, UK.
  11. Tsai, S.J., and Sheen, L.Y. 1989. Essential oil of Ocimum basilicum L. cultivated in Taiwan. In "Trends in Food Science", p.66-77. A.H. Ghee, L.W. Sze, and F.C. Woo Ed., Singapore Institute of Food Science and Technology, Singapore, ISBN 981-00-0949-6.
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计画期间
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研究方向
沈立言老师之研究欲结合中西医食品营养的各家观点与长处，利用细胞、动物与人体实验模式进行保健食品与食疗养生之相关研究，以提供人类养生保健之高附加价值食品。

研究分为4大组
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自1993年起所执行之国科会、农委会及行政院卫生署研究计画，主要利用细胞、动物与人体实验模式，针对大蒜、九层塔、七层塔、牛樟芝、灵芝、巴西洋菇、薑、天麻、金针花等具有重要生理机能性之食品素材进行研究，包括肝脏解毒代谢、抗氧化、细胞代谢产物、抑癌、细胞凋亡、细胞周期、讯息传递、抗忧郁、食物属性等方向之探讨。累积上述多年之研究经验，期望将此等保健食品与食疗养生之研究成果，对于提升人类的生活品质有所助益，且相关学术研究成果也获业界的爱戴，历年皆有机会和食品公司及生技公司合作，以利保健食品之认证与推广。

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人体试验方面 ，利用脉诊仪与甲襞微循环仪，测试不同体质的人对寒性及热性食物之生理反应。探讨传统中医食物分类与人体生理反应的相关性。
近期本食疗研究室承蒙台大食品与分子生物研究中心江文章教授与爱之味公司总裁陈哲芳先生及研发总监陈冠翰博士大力支持得以将本食疗研究室传统中医食疗抗忧郁研究得以产品化，以期实能将研究成果与日常生活做结合。

 


 
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国立中兴大学食品科学系 学士 ( 1984 )
国立中兴大学食品科学研究所 硕士 ( 1986 )
国立中兴大学食品科学研究所 博士 ( 1990 )
（含美国罗格斯大学食品科学研究所公费留学）
现职
-国立台湾大学 食品科技研究所  特聘教授
-国立台湾大学 国家食品安全教育暨研究中心  主任
-国立台湾大学 食品与生物分子研究中心  主任
-台湾食品保护协会 (国际食品保护协会-台湾分会)   理事长
-国立台湾大学医学院 中草药学程小组  委员
-十二年国民基本教育健康与体育领域课程纲要研修小组  委员
-卫生福利部食品药物管理署 健康食品审议小组  委员
-台湾传统暨替代医学协会  理事长
-考试院考选部  典试委员及命题委员
-103年度卫生福利部政策白皮书 (财团法人台湾医界联盟基金会) 食品药物管理小组  召集人
-Journal of Traditional and Complementary Medicine   总编辑
-ISRN Toxicology Journal   编辑委员
-Journal of Food and Drug Analysis   编辑委员
-Nutrition Research and practice   编辑委员
-Food Science and Human Wellness   编辑委员
-European Journal of Toxicological Sciences    编辑委员
-Environmental Stressors in Biology and Medicine   编辑委员
-食品药物管理局 食品药物化粧品审查委员会  委员
-食品药物管理局 健康食品审议委员会  委员
-食品药物管理局 广告标示审议委员会  召集人
-食品药物管理局 健康食品及胶囊锭状食品非预期反应谘议委员会 委员
-经济部工业局 CITD民生食品类组  召集人
-经济部工业局 中小企业即时技术辅导 委员
-国家科学委员会 保健营养学门  初审及复审委员
-台湾保健食品学会  理事
-台湾食品科技学会  理事
-海峡两岸学术文化交流协会  理事 
-海峡两岸学术文化交流协会 保健食品研究会  会长
■经历
-经济部工业局 CITD民生食品类组 委员
-经济部工业局 中小企业即时技术辅导 召集人
-台湾营养学会 副秘书长
-台湾营养学会 理事
-国立台湾大学 食品科技研究所副教授
-台湾保健食品学会 常务理事
-中国医药学院 营养学系暨医学营养学系系主任
-台中市营养公会 理事
-海峡两岸学术文化交流协会 保健食品研究会副会长
-中国医药学院 营养学系副教授
教学荣誉
  1. 荣获2004年国立台湾大学院级教学优良奖。
  2. 荣获2008年国立台湾大学校级教学优良奖。
  3. 荣获2009年国立台湾大学校级教学优良奖。
  4. 荣获2010年国立台湾大学校级教学杰出奖。


一般性学术研究成就

  1. 荣获1997-1999年度国科会甲种研究奖。
  2. 荣获2000年许鸿源博士中医药学术奖。
  3. 荣获2001年度中华民国营养学会陈尚球教授纪念学术奖。
  4. 荣获2002年起国科会研究奖励。
  5. 担任国科会初审与复审委员。
  6. 荣获台湾农业化学会2009年学术荣誉奖。
  7. 荣获台湾食品科学技术学会2009年食品学术研究荣誉 奖。
  8. 荣获台湾营养学会2010年营养学术研究杰出奖。
  9. Sheen, L.Y.* 2002. Effect of sulfur-containing active principles in garlic on the physiological function of hepatocytes. The Fifteenth Annual and International Meeting of Japanese Association for Animal Cell Technology. Fuchu, Tokyo, Japan. (Invited Speaker)
  10. 荣登Who’s Who in Medicine and Healthcare, 2004-2005 (Marquis Who’s Who, USA)。
  11. Sheen, L.Y.* 2006. Current status and developing trend of Health Foods in Taiwan. Food Summit in China 2006, Xiamen, China. (Invited Speaker)
  12. Su, Z.Y., Sun Hwang, Lucy, Kuo, Y.H., Shu, C.H. and Sheen, L.Y.* 2007. Active components of Agaricus blazei fermentation products and their antihepatoma effects. 10th Asian Congress of Nutrition, Taipei, Taiwan. (Invited Speaker, Session Chairperson, and Session Organizer)
  13. Sheen, L.Y.,* Wang, H.C., Tsai, C.W, Wu, C.C. and Lii, C.K. 2007. Regulation of glutathione-related antioxidation and detoxification system in liver by allyl sulfides of garlic oil. ICoFF 2007 International Congress of Food Factors for Health Promotion, Kyoto, Japan. (Invited Speaker and Session Chairperson)
  14. 沈立言*，2008，化学性肝损伤与肝癌之护肝研究。台湾保健食品学会年会暨保健食品与护肝研讨会获邀为invited speaker，台北、台湾。
  15. 沈立言*，2009，中医食疗抗忧郁之研究-以天麻为例。台湾保健食品学会年会暨保健食品与抗忧郁研讨会获邀为invited speaker，台北、台湾。
  16. Sheen, L.Y.* 2009. Anti-proliferation and inhibitory mechanism in various human hepatocellular carcinoma cells by ethanolic extract of mycelia of Antrodia cinnamomea. International Conference on Dietary and Chemical Cancer Prevention: Basic Research and Clinical, Taipei, Taiwan. (Invited Speaker, Session Chairperson, and Conference Organizer)
  17. 指导研究生陈与国及张惠琦同学荣获2009年第三届ZESPRI®舒畅身心蔬果真健康百万论文奖。
  18. 指导研究生陈与国与苏正元同学荣获2009年台大生农学院博士生学术论文奖。
  19. 指导研究生苏正元同学荣获2009年台湾农业化学会优良壁报论文奖。
  20. Sheen, L.Y.* 2009. Anti-proliferation and inhibitory mechanism in various human hepatocellular carcinoma cells by ethanolic extract of mycelia of Antrodia cinnamomea. International Conference on Dietary and Chemical Cancer Prevention: Basic Research and Clinical, Taipei, Taiwan. (Invited Speaker, Session Chairperson, and Conference Organizer)
  21. 沈立言*，2009，财团法人药害救济基金会主办（行政院卫生署食品卫生处协办）演讲『健康食品概论暨食品安全』。
  22. Sheen, L.Y.* 2009. Physiological signals of healthy people with different personal constitutions induced by different attributes of food ingredients – aged ginger tea and coconut water. Global Chinese Health (Functional) Food Symposium, Hong Kong. (Invited Speaker)
  23. 荣登Who’s Who in Medicine and Healthcare, 2009-2010 (Marquis Who’s Who, USA)。
  24. 沈立言*，2009，健康食品的安全性，台湾家庭医学医学会九十八年度秋季学术研讨会。
  25. 沈立言*，2009，抗忧郁食疗之探讨。精神药物学术研讨会。
  26. 2011年通过国立台湾大学生物资源暨农学院教师免评鑑。
  27. 2011, Editor-in-Chief, Journal of Traditional and Complementary Medicine. (PubMed)
  28. Wang, H.C., Pao, J., Lin, S.Y. and Sheen, L.Y.* 2012. Molecular mechanisms of garlic derived allyl sulfides in the inhibition of skin cancer progression. 3rd International Conference on Nutrition and Physical Activity in Aging, Obesity, and Cancer (NAPA 2012), Korea. (Invited Speaker)
  29. Chen, P.J. Chen, E., Lin, S.H., Sheen, L.Y.* 2012. Antidepression Mechanisms of Gastrodia elata Bl. International Conference of Traditional Chinese Medicine and Adaptation to Environmental Stress, Taichung, Taiwan. (Invited Speaker)
  30. Sheen, L.Y.* 2013. Affiliate Member Education Award. 2013 International Association for Food Protection (IAFP). July 28-31, North Carolina, USA.
  31. Chu, Y.L., Raghu, R., Liu, C.T. and Sheen, L.Y.* 2013. Novel mechanism of hepatoprotection by garlic. 4rd International Conference on Nutrition and Physical Activity in Aging, Obesity, and Cancer (NAPA 2013). Aug. 14-17, Pattaya, Thailand. (Invited Speaker)
  32. Lin, S.H., Chen, W.C., and Sheen, L.Y.* 2013. Brain health and traditional Chinese herbal medicine: Gastrodia elata blume. 2013 KNS-Cheonan International Symposium, Aug. 30-Sep. 15, Korea. (Invited Speaker)
  33. Sheen, L.Y.* 2013. International Conference of Traditional and Complementary Medicine on Health. May 24-26, Taipei, Taiwan. (附件一)
  34. Sheen, L.Y.* 2013. The 3rd Asia Pacific International Conference on Food Safety. Oct. 29-Nov. 1, Taipei, Taiwan. (附件二)
  35. Sheen, L.Y.* 2014. The 4th Mind-Body Interface International Symposium, Feb. 21, Taichung, Taiwan. (Session chairperson)
  36. Sheen, L.Y.* 2014. Global trends on food safety management. International Symposium on Autonomous Safety Management for Foodservice. Apr. 23, Taipei, Taiwan. (Invited Speaker, Session Chairperson, and Conference Organizer)
  37. Sheen, L.Y.* and Kuo, C.H. 2014. Developing high BMI in Taiwan schoolchildren with sedentary behavior- link to parental metabolic status. Global Forum 2014 for Physical Education Pedagogy, May 15-17, South Africa. (Invited Speaker)
  38. 指导研究生赖奕瑄及曾惠君同学荣获 2014 年第八届ZESPRI® 舒畅身心蔬果真健康百万论文奖。
  39. 指导研究生张惠萍荣获 2014 年台湾营养学会第 40 届年会 “营养推广教育贡献奖”。
  40. Sheen, L.Y.*2014. Affiliate Education Award. 2014 International Food Protection Association (IAFP). Aug. 3-6, Indianapolis, Indiana.
  41. Sheen, L.Y.*2014. Best Affiliate Overall Meeting Award. 2014 International Food Protection Association (IAFP). Aug. 3-6, Indianapolis, Indiana.
  42. Sheen, L.Y.* 2014. Review of anticancer activities and its mechanism of Antrodia cinnamomea. Session Chairperson. 10th International symposium on biocatalysis and agriculture biotechnology (ISBAB) Oct 28-31, Kaohsiung, Taiwan. (Session Chairperson)
  43. Sheen, L.Y. * 2014. Taiwan MICE (Meetings, Incentive, Conventions, Exhibitions) Silver Award.
  44. Sheen, L.Y. * 2014. How to let children eat safely such as beverages, starch, coloring, and Health Foods. Children's Food Security Forum, Mackay Memorial Hospital, Taipei, Taiwan. (Invited Speaker)
  45. Sheen, L.Y.* 2014. Global trends on food safety management. International Symposium on Autonomous Safety Management for Foodservice. Apr. 23, Taipei, Taiwan. (Invited Speaker, Session Chairperson, and Conference Organizer)
  46. 指导研究生吴伟恺同学荣获 2014 ILSI SEA conference "Best Poster Award" in the conference of "THE GUT, ITS MICROBES, AND HEALTH." Oct. 8-9, Singapore.
  47. Sheen, L.Y.,* Chen, W.C., Lin, S.H., and Chou, Y.Y. 2014. Brain health and traditional Chinese herbal medicine: Gastrodia elata Blume (天麻 tiān má). 17th International Congress of Oriental Medicine (ICOM). Nov 1-3, Taipei, Taiwan. (Invited Speaker, Session Chairperson, and Conference Organizer)
  48. Lai, Y.S. and Sheen, L.Y.* 2014. Garlic essential oil attenuates high fat diet-induced nonalcoholic fatty liver disease mainly via SREBP-1c and PPARα pathway. 5rd International Conference on Nutrition and Physical Activity in Aging, Obesity, and Cancer (NAPA 2014). Nov.14-17, Xi’an, China. (Invited Speaker, Session chairperson and Conference Organizer)

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