NTU Food Science & Tech.

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Lee-Yan Sheen
Professor
Job Title Distinguished Professor and Director of Center for Food and Biomolecules
Name Lee-Yan Sheen
Office Tel No. 02-3366-1572
Email lysheen@ntu.edu.tw
Education Doctor of Philosophy in Food Science, National Chung-Hsing University
Research Expertise Food Diet Study
Personal Website https://fo93316.wixsite.com/website
 
  1. Wu, W.K., Chen, C.C., Liu, P.U., Panyod, S., Liao, B.Y., Chen, P.C., Kao, H.L., Kuo, H.C., Kuo, C.H., Chiu, H.T., Chen, R.A., Chuang, H.L., Huang, H.T., Zou, H.B., Hsu, C.C., Chang, T.Y., Lin, C.L., Ho, C.T., Yu, H.T., Sheen, L.Y.*, Wu, M.S. 2018. Identification of TMAO-producer phenotype and host–diet–gut dysbiosis by carnitine challenge test in human and germ-free mice. Gut, doi:10.1136/gutjnl-2018-317155.
  2. Huang, C.Y., Sheen, S.*, Sommers, C., Sheen, L.Y.* 2018. Modeling the survival of Escherichia coli O157:H7 under hydrostatic pressure, process temperature, time and allyl isothiocyanate stresses in ground chicken meat. Frontiers in Microbiology, 9: 1871.
  3. Wang, P.S., Kuo, C.H., Yang, H.C., Liang, Y.J., Huang, C.J., Sheen, L.Y., Pan, W.H. 2018. Postprandial metabolomics response to various cooking oils in humans. Journal of Agricultural and Food Chemistry, 66(19): 4977-4984.
  4. Wu, W.K., Panyod, S., Chen, C.C., Kuo, H.C., Liu, P.Y., Kuo, C.H., Chen, R.A. Sheen, L.Y.*, Wu, M.S. 2018. 747 - Gavage of fecal microbiota from TMAO producer characterized by modified carnitine challenge test reproduces the TMAO formation phenotype in germ free mice. Gastroenterology, 154(6): 156-157.
  5. Lin, Y.E., Chou, S.T., Lin, S.H., Lu, K.H., Panyod, S., Lai, Y.S., Ho, C.T., Sheen, L.Y.* 2018. Antidepressant-like effects of water extract of Gastrodia elata Blume on neurotrophic regulation in a chronic social defeat stress model. Journal of Ethnopharmacology, 215: 132-139.
  6. Sommers, C., Huang, C. Y., Sheen, L.Y., Sheen, S., Huang, L. 2018. Growth modeling of uropathogenic Escherichia coli in ground chicken meat. Food Control, 86: 397-402.
  7. Lin, Y.E., Lu, K.H., Sheen, L.Y.* 2018. Recent research progress on the antidepressant-like effect and neuropharmacological potential of Gastrodia elata Blume. Current Pharmacology Reports, 4(3): 220-237.
  8. Wu, W.K., Chen, C.C., Panyod, S., Chen R.A., Wu, M.S., Sheen, L.Y.*, Chang, S.C. 2018. Optimization of fecal sample processing for microbiome study - The journey from bathroom to bench. Journal of the Formosan Medical Association, doi: 10.1016/j.jfma.2018.02.005.
  9. Cheng, B.H., Sheen, L.Y., Chang, S.T. 2018. Hypolipidemic effects of S-(+)-linalool and essential oil from Cinnamomum osmophloeum ct. linalool leaves in mice. Journal of Traditional and Complementary Medicine, 8(1): 46-52.
  10. Huang, H.L., Lim, S.L., Lu, K.H., Sheen, L.Y.* 2018. Antidepressant-like effects of Gan-Mai-Dazao-Tang via monoamine regulatory pathways on forced swimming test in rats. Journal of Traditional and Complementary Medicine, 8(1): 53-59.
  11. Lu, K.H., Weng, C.Y., Chen, W.C., Sheen, L.Y.* 2017. Ginseng essence, a medicinal and edible herbal formulation, ameliorates carbon tetrachloride-induced oxidative stress and liver injury in rats. Journal of Ginseng Research, 41(3): 316-325.
  12. Wang, H.C., Chu, Y.L., Hsieh, S.C., Sheen, L.Y.* 2017, Jun. Diallyl trisulfide inhibits cell migration and invasion of human melanoma A375 cells via inhibiting intergrin/facal adhision kinase pathway. Environmental Toxicology, 32(11): 2352-2359.
  13. Hsu, W.F., Sheen, L.Y., Lin, H.J., Chang, H.H. 2016. A review of western and traditional Chinese medical approaches to managing nonalcoholic fatty liver disease. Evidence-Based Complementary and Alternative Medicine, 2016:6491420. Epub 2016 Oct 31.
  14. Chien, S.Y., Sheen, S.*, Sommers, C., Sheen, L.Y. 2016. Modeling the inactivation of Escherichia coli O157:H7 and uropathogenic E. coli in ground beef by high pressure processing and citral. Food Control, 73: 672-680.
  15. Panyod, S., Wu, W.K., Ho, C.T., Lu, K.H., Liu, C.T., Chu, Y.L., Lai, Y.S., Chen, W.C., Lin, Y.E., Lin, S.H., Sheen, L.Y.* 2016. Diet supplementation with allicin protects against alcoholic fatty liver disease in mice by improving anti-inflammation and antioxidative functions. Journal of Agricultural and Food Chemistry, 64(38): 7104-7113.
  16. Huang, W.F., Hong, T.W., Wang, Y.J., Chen, K.C., Pei, J.C., Chuang, T.Y., Lai, W.S., Tsai, S.H., Chu, R., Chen, W.C., Sheen, L.Y., Takahasi, S., Ding, S.T., Shen, T.L. 2016. Ophiocordyceps formosana improves hyperglycemia and depression-like behavior in an STZ-induced diabetic mouse model. BMC Complementary and Alternative Medicine, 16(1): 310.
  17. Chien, S.Y., Sheen, S.*, Sommers, C.H., Sheen, L.Y. 2016. Modeling the inactivation of intestinal pathogenic Escherichia coli O157: H7 and uropathogenic E. coli in ground chicken by high pressure processing and thymol. Frontiers in Microbiology, 7(920): 1-11.
  18. Lin, Y.E., Lin, S.H., Chen, W.C., Ho, C.T., Lai, Y.S., Panyod, S., and Sheen, L.Y.* 2016. Antidepressant-like effects of water extract of Gastrodia elata Blume in rats exposed to unpredictable chronic mild stress via modulation of monoamine regulatory pathways. Journal of Ethnopharmacology, 187: 57-65.
  19. Lu, K.H., Pan, Y.C., Sheen, L.Y.* 2016. Reflection on food safety incidents in Taiwan: From crisis response to risk management. Journal of Chinese Dietary Culture (in Chinese), 12(1): 245-271.
  20. Lai, Y.S., Lee, W.C., Lin, Y.E., Ho, C.T., Lu, K.H., Lin, S.H., Panyod, S., Chu, Y.L., Sheen, L.Y.* 2016. Ginger essential oil ameliorates hepatic injury and lipid accumulation in high fat diet-induced nonalcoholic fatty liver disease. Journal of Agricultural and Food Chemistry, 64(10): 2062-2071.
  21. Chen, W.C., Lai, Y.S., Lin, S.H., Lu, K.H., Panyod, S., Ho, C.T., Sheen, L.Y.* 2016. Anti-depressant effects of Gastrodia elata Blume and its compounds, gastrodin and 4-hydroxybenzyl alcohol, involve the monoaminergic system and neuronal cytoskeletal remodeling processes. Journal of Ethnopharmacology, 182: 190-199.
  22. Lin, S.H, Chou, M.L., Chen, W.C., Lai, Y.S., Lu, K.H., Hao, C.W., Chu, Y.L., Sheen, L.Y.* 2015. Antidepressant-like activity of the water extract of Melissa officinalis L. in forced swimming test via regulation of the serotonergic neurotransmitter. Journal of Ethnopharmacology, 175: 266-272.
  23. Lai, Y.S., Chen, W.C., Kuo, T.C., Ho, C.T., Kuo, C.H., Tseng, Y, Lu, K.H., Lin, S.H. Panyod, S., Sheen, L.Y.* 2015. Mass spectrometry-based serum metabolomics of a C57BL/6J mouse model of high-fat diet induced nonalcoholic fatty liver disease development. Journal of Agricultural and Food Chemistry, 63(35): 7873-7884.
  24. Wu, W.K., Panyod, S., Ho, C.T., Kuo, C.H., Wu, M.S., Sheen, L.Y.* 2015. Dietary allicin reduces transformation of L-carnitine to TMAO through impact on gut microbiota. Journal of Functional Foods, 15: 408-417.
  25. Huang, L.Y., Chu, Y.L., Ho, C.T., Chung, J.G., Lai C.I., Su, Y.C., Kuo, Y.H., Sheen, L.Y.* 2015. Antcin K, an active triterpenoid from the fruiting bodies of basswood cultivated Antrodia cinnamomea, inhibits metastasis via suppression of integrin-mediated adhesion, migration, and invasion in human hepatoma cells. Journal of Agricultural and Food Chemistry, 63(18): 4561-4569.
  26. Chen, W.C., Lai, Y.S., Lu, K.H., Lin, S.H., Liao, L.Y., Ho, C.T., Sheen, L.Y.* 2015. Method development and validation for the HPLC assay of gastrodin in water extracts from different sources of Gastrodia elata Blume. Journal of Food and Drug Analysis, 23(4): 803-810.
  27. Cheng, B.H., Sheen, L.Y., Chang, S.T. 2015. Evaluation of anxiolytic potency of essential oil and S-(+)-linalool from Cinnamomum osmophloeum ct. linalool leaves in mice. Journal of Traditional and Complementary Medicine, 5(1): 27-34.
  28. Lu, K.H. and Sheen, L.Y.* 2015. How do consumers protect themselves from the impact of food safety incidents. Judicial Aspiration (in Chinese), 113: 25-29.
  29. Chen, P.B., Wang, H.C., Liu, Y.W., Lin, S.H., Chou, H.N., Sheen L.Y.* 2014. Immunomodulatory activities of polysaccharides from Chlorella pyrenoidosa in a mouse model of Parkinson’s disease. Journal of Functional Foods, 11: 103-113.
  30. Lin, S.H., Chen, W.C, Lu, K.H., Chen, P.J., Hsieh, S.C. Pan, T.M., Chen, S.T., Sheen, L.Y.* 2014. Down-regulation of Slit-Robo pathway mediating neuronal cytoskeletal remodeling processes facilitates the antidepressive-like activity of Gastrodia elata Blume. Journal of Agricultural and Food Chemistry, 62(43): 10493-10503.
  31. Chang, H.P., Sheen L.Y., Lei, Y.P. 2014. The protective role of carotenoids and polyphenols in patients with head and neck cancer. Journal of the Chinese Medical Association, 78(2): 89-95.
  32. Lai, Y.S., Chen, W.C., Ho, C.T., Lu, K.H., Lin, S.H., Tseng, H.C., Sheen, L.Y.* 2014. Garlic essential oil protects against obesity-triggered nonalcoholic fatty liver disease through modulation of lipid metabolism and oxidative stress. Journal of Agricultural and Food Chemistry, 62(25): 5897-5906.
  33. Lo, W.Y., Sheen, L.Y., Lo, Y.C., Hsieh, S.C. 2014. The effects of blackcurrant on anti-inflammation and prevention of allergic respiratory diseases syndrome. Journal of Agricultural Chemistry and Food Science, 52(1): 25-30.
  34. Lu, K.H., Tseng, H.C., Liu, C.T., Huang, C.J., Chyuanc, J.H., Sheen, L.Y.* 2014. Wild bitter gourd protects against alcoholic fatty liver in mice by attenuating oxidative stress and inflammatory responses. Food and Function, 5(5): 1027-1037.
  35. Liu, Y.T., Lo, Y.C., Hsieh, S.C., Sheen, L.Y.* 2013. The antioxidant activity of blackcurrant and its effects on Parkinson's disease and Alzheimer's disease. Nutrition Society of Taiwan (in Chinese), 38(4): 120-131.
  36. Chu, Y.L., Chimeddulam, D., Sheen, L.Y.*, Wu, K.Y. 2013. Probabilistic risk assessment of exposure to leucomalachite green residues from fish products. Food and Chemical Toxicology, 62: 770-776.
  37. Liu, C.T., Raghu, R., Lin, S.H., Wang, S.Y., Kuo, C.H., Tseng, Y.J., Sheen, L.Y.* 2013. Metabolomics of ginger essential oil against alcoholic fatty liver in mice. Journal of Agricultural and Food Chemistry, 61(46): 11231-11240.
  38. Chu, Y.L., Ho, C.T., Chung, J.G., Rajasekaran R., Lo Y.C., Sheen, L.Y.* 2013. Allicin induces anti-human liver cancer cells through the p53 gene modulating apoptosis and atophagy. Journal of Agricultural and Food Chemistry, 61: 9839-9848.
  39. Chen, S.F., Hu, T.M., Lan, T.H., Chiu, H.J., Sheen, L.Y.*, Loh, E.W. 2013. Severity of psychosis syndrome and change of metabolic abnormality in chronic schizophrenia patients: Severe negative syndrome may be related to a distinct lipid pathophysiology. European Psychiatry, 29(3): 167-171.
  40. Chu, Y.L., Rajasekaran, R., Lu, K.H., Liu, C.T., Lin, S.H., Lai, Y.S., Chen, W.C., Lin, S.H., Sheen, L.Y.* 2013. Autophagy therapeutic potential of garlic in human cancer therapy. Journal of Traditional and Complementary Medicine, 3(3): 159-162.
  41. Lin, S.H., Chang, H.C., Chen, P.J., Hsieh, C.L., Su, K.P., Sheen, L.Y.* 2013. The antidepressant-like effect of ethanol extract of daylily flowers (金針花 Jīn Zhēn Huā ) in rats. Journal of Traditional and Complementary Medicine, 3(1): 53-61.
  42. Raghu R., Liu, C.T., Tsai, M.H., Tang, X., Kalari, K.R., Subramanian, S., and Sheen, L.Y.* 2012. Transcriptome analysis of garlic induced hepatoprotection against alcoholic fatty liver. Journal of the Agricultural and Food Chemistry 60(44): 11104-11119.
  43. Wu, C.C., Chu, Y.L., and Sheen, L.Y.* 2012. Allicin modulates the antioxidation and detoxification capability in primary rat hepatocytes. Journal of Traditional and Complementary Medicine 2(4): 323-330.
  44. Su, Y.C., Liu, C.T., Raghu, R., Kuo, Y.H., and Sheen, L.Y.* 2012. Eburicoic acid, an active triterpenoid from the fruiting bodies of basswood cultivated Antrodia cinnamomea, induces ER stress-mediated autophagy in human hepatoma cells. Journal of Traditional and Complementary Medicine 2(4): 312-322.
  45. Liu, Y.W., Lu, K.H., Ho, C.T., and Sheen, L.Y.* 2012. Protective effects of Antrodia cinnamomea against liver injury. Journal of Traditional and Complementary Medicine 2(4): 284-294.
  46. Wang H.C., Pao, J., Lin, S.Y., and Sheen, L.Y.* 2012. Molecular mechanisms of garlic-derived allyl sulfides in the inhibition of skin cancer progression. Annals of the New York Academy of Sciences 1271(1): 44-52.
  47. Chu, Y.L., Ho, C.T., Chung, J.G., Raghu, R., and Sheen, L.Y.* 2012. Allicin induces p53-mediated autophagy in Hep G2 human liver cancer cells. Journal of the Agricultural and Food Chemistry 60(34): 8363-8371.
  48. Raghu, R., Lu, K.H., and Sheen, L.Y.* 2012. Recent research progress on garlic (大蒜 dà suàn) as a potential anticarcinogenic agent against major digestive cancers. Journal of Traditional and Complementary Medicine 2(3): 192-201.
  49. Lu, K.H., Liu, C.T., Raghu, R., and Sheen, L.Y.* 2012. Therapeutic potential of Chinese herbal medicines in alcoholic liver disease. Journal of Traditional and Complementary Medicine 2(2): 115-122.
  50. Liu, C.T., Hsu, T.W., Chen, K.M., Tan, Y.P., Lii, C.K., and Sheen, L.Y.* 2012. The antidiabetic effect of garlic oil is associated with ameliorated oxidative stress but not ameliorated level of pro-inflammatory cytokines in skeletal muscle of streptozotocin-induced diabetic rats. Journal of Traditional and Complementary Medicine 2(2): 135-144.
  51. Tsai, C.W., Chen, H.W., Sheen, L.Y., and Lii, C.K. 2012. Garlic: Health benefits and actions. BioMedicine 2(1): 17-29.
  52. Tung, Y.C., Su, Z.Y., Kuo, M.L., and Sheen, L.Y.* 2012. Ethanolic extract of Agaricus blazei fermentation product inhibits the growth and invasion of human hepatoma HA22T/VGH and SK-Hep-1 cells. Journal of Traditional and Complementary Medicine 2(2): 145-153.
  53. Chen, I.S., Chen, Y.C., Chou, C.H., Chuang, R.F., Sheen, L.Y., and Chiu, C.H. 2012. Hepatoprotection of silymarin against thioacetamide-induced chronic liver fibrosis. Journal of the Science of Food and Agriculture 92(7): 1441-1447. (SCI)
  54. Wang, H.C., Hsieh, S.C., Yang, J.H., Lin, S.Y., and Sheen, L.Y.* 2012. Diallyl trisulfide induces apoptosis of human basal cell carcinoma cells via endoplasmic reticulum stress and the mitochondrial pathway. Nutrition and Cancer 64(5): 770-780. (SCI)
  55. Chen, P.J., Pang, V.F., Jeng, Y.M. Chen, T.J., Hu, F.C., Chi, W.T., Chou, H.Y., Chiu, H.C., Lee, Y.C., and Sheen, L.Y.* 2012. Establishment of a standardized animal model of chronic hepatotoxicity using acetaminophen-induced hepatotoxicity in the evaluation of hepatoprotective effects of health food. Journal of Food and Drug Analysis 20(1): 43-49. (SCI)
  56. Wang, Y.W., Lii, C.K., Sheen, L.Y., and Liu, C.T. 2011. The effect of garlic oil on insulin secretion in HIT-T15 cells. Nutritional Science Journal 36 (4): 29-39.
  57. Chao, D.P., Tyan, C.C., Chen, J.J., Hsieh, C.L., and Sheen, L.Y.* 2011. Effect of hot-attribute aged ginger tea on Chinese medical pulse condition of healthy young humans. Journal of Traditional and Complementary Medicine 1(1): 69-75.
  58. Chen, P.J. and Sheen, L.Y.* 2011. Gastrodiae Rhizoma (天麻 tiān má): a review of biological activity and antidepressant mechanisms. Journal of Traditional and Complementary Medicine 1(1): 31-40.
  59. Chao, D.P., Chen, J.J., Huang, S.Y., Tyan C.C., Hsieh C.L., and Sheen, L.Y.* 2011. Effects of hot and cold foods on signals of heart rate variability and nail fold microcirculation of healthy young humans: a pilot study. Chinese Journal of Physiology 54 (3): 145-152. (SCI)
  60. Su, Z.Y., Tung, Y.C., Hwang, L.S., and Sheen, L.Y.* 2011. Blazeispirol A from Agaricus blazei fermentation product induces cell death in human hepatoma Hep 3B cells through caspase-dependent and caspase-independent pathways. Journal of the Agricultural and Food Chemistry 59 (9): 5109-5116. (SCI)
  61. Chen, P.J., Liang, K.C., Lin, H.C., Hsieh, C.L., Su, K.P., Hung M.C., and Sheen, L.Y.* 2011. Gastrodia elata Bl. Attenuated learning deficits induced by forced-swimming stress in the inhibitory avoidance task and Morris water maze. Journal of Medicinal Food 14 (6): 610-617. (SCI)
  62. Chi, H.M., Chou, S.T., Lin, S.C., Su, Z.Y., and Sheen, L.Y.* 2010. Protective effects of water extract of clam on normal and CCl4-induced damage in primary rat hepatocytes. The American Journal of Chinese Medicine 38 (6): 1193-1205. (SCI)
  63. Liao, C.L., Huang H.Y., Sheen, L.Y., and Chou, C.C. 2010. Anti-inflammatory activity of soymilk and fermented soymilk prepared with lactic acid bacterium and bifidobacterium. Journal of Food and Drug Analysis 18 (3): 202-207. (SCI)
  64. Wang, H.C., Yang, J.H., Hsieh S.C., and Sheen, L.Y.* 2010. Allyl sulfides inhibit cell growth of skin cancer cells through induction of DNA damage mediated G2/M arrest and apoptosis. Journal of the Agricultural and Food Chemistry 58(11): 7096-103. (SCI)
  65. Lin, Y.W., Pan, J.H., Sheen, L.Y., Liu, R.H., Kuo, Y.H., and Chiang, B.H. 2010. The 4-acetylantroquinonol B isolated from mycelium of Antrodia cinnamomea inhibits proliferation of hepatoma cells. Journal of the Science of Food and Agriculture 90 (10): 1739-1744. (SCI)
  66. Lin, S.Y., Sheen, L.Y., Chiang, B.H., Yang, J.S., Pan, J.H., Chang, Y.H., Hsu, Y.M., Chiang, J.H., Lu, C.C., Wu, C.L., and Chung, J.G. 2010. Dietary effect of Antrodia camphorate extracts on immune responses in WEHI-3 leukemia BALB/c mice . Nutrition and Cancer 62 (5): 593-600. (SCI)
  67. Wang, Y.J., Sheen, L.Y., and Chou, C.C. 2010. Storage effects on the content of anthocyanin, mutagnicity and antimutagenicity of black soybean koji. International Journal of Food Science and Technology 43 (4): 702-707. (SCI)
  68. Lei, Y.P., Liu, C.T., Sheen, L.Y., Chen H.W., and Lii, C.K. 2010. Diallyl disulfide and diallyl trisulfide protect endothelial nitric oxide synthase against damage by oxidized low-density lipoprotein. Molecular Nutrition and Food Research 54 (suppl 1): S42-52. (SCI)
  69. Huang, R.Y., Wang, Y.J., Sheen, L.Y., and Chou, C.C. 2010. Storage temperature and packaging condition affect the total phenolic content and antioxidant activity of black soybeans and koji. International Journal of Food Science and Technology 45 (3): 437-443. (SCI)
  70. Chen, P.J., Hsieh, C.L., Su, K.P., Hou, Y.C., Jiang, X.M., Lin, I.H., and Sheen, L.Y.* 2009. Rhizomes of Gastrodia elata Bl. possess antidepressant-like effect via monoamine modulation in subchronic animal model. The American Journal of Chinese Medicine 37 (6): 1113-1124. (SCI)
  71. Chen, Y.K., Kuo, Y.H., Chiang, B.H., Lo, J.M., and Sheen, L.Y.* 2009. Cytotoxic activities of 9,11-dehydroergosterol peroxide and ergosterol peroxide from the fermentation mycelia of Ganoderma lucidum cultivated in the medium containing leguminous plants on Hep 3B cells. Journal of the Agricultural and Food Chemistry 57 (13): 5713-5719. (SCI)
  72. Liu, C.T., Su, H.M., Lii, C.K., and Sheen, L.Y. 2009. Effect of supplementation with garlic oil on activity of Th1 and Th2 lymphocytes from rats. Planta Medica 75 (3): 205-210. (SCI)
  73. Pan, J.H., Chen, Y.S., Sheen, L.Y., and Chiang, B.H. 2008. Large-scale submerged fermentation of Antrodia cinnamomea for anti-hepatoma activity. Journal of the Science of Food and Agriculture 88: 2223-2230. (SCI)
  74. Su, Z.Y., Hwang, L.S., Kuo, Y.H., Shu, C.H., and Sheen, L.Y.* 2008. Black soybean promotes the formation of active components with antihepatoma activity in the fermentation product of Agaricus blazei. Journal of the Agricultural and Food Chemistry 56 (20): 9447-9454. (SCI)
  75. Lei, Y.P., Chen, H.W., Sheen, L.Y., and Lii, C.K. 2008. Diallyl disulfide and diallyl trisulfide suppress oxidized LDL-induced vascular cell adhesion molecule and E-selectin expression through protein kinase A- and B-dependent signaling pathways. The Journal of Nutrition 138 (6): 996-1003. (SCI)
  76. Chen, Y.S., Pan, J.H., Chiang, B.H., and Sheen, L.Y.* 2008. Ethanolic extracts of Antrodia cinnamomea mycelia fermented at varied times and scales have differential effects on hepatoma cells and normal primary hepatocytes. Journal of Food Science 73 (7): H179-H185. (SCI)
  77. Chen, P.J., Hsieh, C.L., Su, K.P., Hou, Y.C., Jiang, X.M., Lin, I.H., and Sheen, L.Y.* 2008. The antidepressant effect of Gastrodia elata Bl. on the forced-swimming test in rats. The American Journal of Chinese Medicine 36 (1): 95-106. (SCI)
  78. Liu, C.T., Sheen, L.Y., and Lii, C.K. 2007. Does garlic have a role as antidiabetic agent? Molecular Nutrition and Food Research 51 (11): 1353-1364. (SCI)
  79. Tsai, C.W., Chen, H.W., Yang, J.J., Sheen, L.Y., and Lii, C.K. 2007. Diallyl disulfide and diallyl trisulfide up-regulate the expression of the π class of glutathione S-transferase via an AP-1-dependent pathway. Journal of the Agricultural and Food Chemistry 55 (3): 1019-1026. (SCI)
  80. Liu, K.L., Chen, H.W., Wan, R.Y., Lei, Y.P., Sheen, L.Y., and Lii, C.K. 2006. DATS reduces LPS-induced iNOS expression, NO production, oxidative stress and NF-κB activation in RAW  264.7 macrophages. Journal of the Agricultural and Food Chemistry 54 (9): 3472-3478. (SCI)
  81. Lin, W.C., Liao, Y.C., Liau, M.C., and Sheen, L.Y.* 2006. Inhibitory effect of CDA-II, a urinary preparation, on alflatoxin B1-induced DNA damage in primary rat hepatocytes. Food and Chemical Toxicology 44 (4): 546-551. (SCI)
  82. Tsai, C.W., Yang, J.J., Chen, H.W., Sheen, L.Y., and Lii, C.K. 2005. Garlic organosulfur compounds up-regulate the expression of the π class of glutathione S-transferase in rat primary hepatocytes. Journal of Nutrition 135 (11): 2560-2565. (SCI)
  83. Liu, C.T., Hse, H., Lii, C.K., Chen, P.S., and Sheen, L.Y. 2005. Effect of garlic oil and diallyl trisulfide on glycemic control in streptozotocin-induced diabetic rats. European Journal of Pharmacology 516 (2): 165-173. (SCI)
  84. Yang, J.H., Chou, C.C., Cheng, Y.W., Sheen, L.Y., Chou, M.C., Yu, H.S., Wei, Y.H., and Chung, J.G. 2004. Effects of glycolic acid on the induction of apoptosis via caspase-3 activation in human leukemia cell line (HL-60). Food and Chemical Toxicology 42 (11): 1777-1784. (SCI)
  85. Wu, C.C., Chung, J.G., Tsai, S.J., and Sheen, L.Y.* 2004. Differential effects of allyl sulfides from garlic essential oil on cell cycle regulation in human liver tumor cells. Food and Chemical Toxicology 42 (12): 1937-1947. (SCI)
  86. Wu, C.C., Lii, C.K., Tsai, S.J., and Sheen, L.Y.* 2004. Diallyl trisulfide modulates cell viability and the antioxidation and detoxification systems of rat primary hepatocytes. Journal of Nutrition 134 (4): 724-728. (SCI)
  87. Kao, M.J. and Sheen, L.Y.* 2003. Effects of infrared and low-power laser irradiation on cell viability, glutathione and glutathione-related enzyme activities in primary rat hepatocytes. Journal of Formosa Medicine Association 102 (7): 486-491. (SCI)
  88. Lin, W.C., Liao, Y.C. Liau, M.C., and Sheen, L.Y.* 2003. Effect of CDA-II on cell viability, lipidperoxidation, glutathione concentration and its related enzyme activities in primary rat hepatocytes. The American Journal of Chinese Medicine 31 (3): 415-423. (SCI)
  89. Wu, C.C., Sheen, L.Y., Chen, H.W., Kuo, W.W., Tsai, S.J., and Lii, C.K. 2002. Differential effects of garlic oil and its three major organosulfur components on the hepatic detoxification system in rats. Journal of the Agricultural and Food Chemistry 50: 378-383. (SCI)
  90. Chen, H.W., Yang, J.J., Tsai, C.W., Wu, C.C., Sheen, L.Y., Ou, C.C., and Lii, C.K. 2001. Dietary fat and garlic oil independently regulate hepatic cytochrome P450 2B1 and the placental form of glutathione S-transferase expression in rats. Journal of Nutrition 131: 1438-1443. (SCI)
  91. Sheen, L.Y.*, Wu, C.C., Lii, C.K., and Tsai, S.J. 2001. Effect of diallyl sulfide and diallyl disulfide, the active principles of garlic, on the alflatoxin B1-induced DNA damage in primary rat hepatocytes. Toxicology Letters 122 (1): 45-52. (SCI)
  92. Chen, C.C., Wang, H.J., Shih, H.C., Sheen, L.Y., Chang, C.T., Chen, R.H., and Wang, T.Y. 2001. Comparison the metabolic effects of metformin and troglitazone on fructose-induced insulin resistance in male Sprague-Dawley rats. Journal of Formosa Medicine 100 (3): 176-180. (SCI)
  93. Wu, C.C., Sheen, L.Y., Chen, H.W., Tsai, S.J., and Lii, C.K. 2001. Effect of organosulfur compounds from garlic oil on the antioxidation system in rat liver and red blood cells. Food and Chemical Toxicology 39 (6): 563-569. (SCI)
  94. Sheen, L.Y., Chen, H.W., Kung, Y.L., Liu, C.T., and Lii, C.K. 1999. Effects of garlic oil and its organosulfur compounds on the activities of hepatic drug-metabolizing and antioxidant enzymes  in rats fed high- and low-fat diets. Nutrition and Cancer 35 (2): 160-166. (SCI)
  95. Sheen, L.Y.*, Wu, C.C., Lii, C.K., and Tsai, S.J. 1999. Metabolites of diallyl disulfide and diallyl sulfide in primary rat hepatocytes. Food and Chemical Toxicology 37 (12): 1139-1146. (SCI)
  96. Sheen, L.Y.*, Sheu, S.F., Tsai, S.J., Meng, R.H.C., and Lii, C.K. 1999. Effect of garlic active principle – diallyl disulfide – on cell viability, lipid peroxidation, glutathione concentration and its related enzyme actives in primary rat hepatocytes. The American Journal of Chinese Medicine 27 (1): 95-105. (SCI)
  97. 林淑媛、許靖宜、陳宇嘉、張錦文、沈立言*1998。醫院營養師對醫院營養部伙食外包廠商考考量及品質之看法。中國醫藥學院雜誌 7 (4): 127-134.
  98. 許靖宜、林淑媛、陳宇嘉、張錦文、沈立言*1998。醫院營養師對於伙食外包可行性之研究。中國醫藥學院雜誌 7 (3): 173-182.
  99. Liu, C.T., Chen, H.W., Sheen, L.Y., Kung, Y.L., Chen, P.C.H., and Lii, C.K. 1998. Effect of garlic oil on hepatic arachidonic acid content and immune response in rats. Journal of the Agricultural and Food Chemistry 46: 4642-4647. (SCI)
  100. Chen, H.W., Lii, C.K., Wu, M.H., Ou, C.C., and Sheen, L.Y. 1997. Amount and type of dietary lipid modulate rat hepatic cytochrome P-450 activity. Nutrition and Cancer 29: 174-180. (SCI)
  101. Lin, C.W., Lin, T.H., Sheen, L.Y., Chung, C.H., and Cheng, K.S. 1997. Diallyl sulfide as a potent inducer on the granulocytic/ macrophagic differentiation of K562 human leukemic cells. Med. J. CMCH 2: 149-154.
  102. 葉佳聖、沈立言、李宗貴、蔡順仁。1997。補骨脂水萃取物及補骨脂酚對大白鼠初代肝細胞之抗氧化保護作用。中華民國營養學會雜誌22 (3): 303-324.
  103. Wang, S.T., Chen, H.W., Sheen, L.Y., and Lii, C.K. 1997. Methionine and cysteine affect glutathione level, glutathione-related enzyme activities and the expression of glutathione S-transferase isozymes in rat hepatocytes. The Journal of Nutrition 127: 2135-2141. (SCI)
  104. Chen, H.W., Ko, J.J., Lii, C.K., Ou, C.C., and Sheen, L.Y. 1997. Corn oil enhances gamma-glutamyl transpeptidase-positive foci development in the presence of phenobarbital during hepatocarcinogenesis in rats. Nutrition and Cancer 28 (3): 252-257. (SCI)
  105. 葉佳聖、沈立言、蔡順仁。1997。補骨脂酚對大白鼠初代肝細胞之抗氧化生理活性之影響。食品科學24 (3): 295-307.
  106. 沈立言*、吳志忠。1997。大蒜素於45oC下在不同油脂中之變化。中華民國營養學會雜誌22 (1): 89-102.
  107. Sheen, L.Y.*, Lii, C.K., Sheu, S.F., Meng, R.H.C., and Tsai, S.J. 1996. Effect of the active principle of garlic – diallyl sulfide – on the cell viability, detoxification capability and antioxidation system of primary rat hepatocytes. Food and Chemical Toxicology 34: 971- 978. (SCI)
  108. Lii, C.K., Wang, S.T., Chen, H.W., and Sheen, L.Y. 1996. Glutathione and glutathione-related enzyme activities of male and female rat hepatocytes under various culture conditions. Archives of Toxicology 70: 822-829. (SCI)
  109. 沈立言*、吳志忠、蔡順仁。1995。大蒜精油在不同油脂中之安定性。中華民國營養學會雜誌20 (4): 381-392.
  110. 沈立言*、呂英震、康志強、林淑媛、蔡順仁。1994。大蒜保健食品中活性成分之定性及定量分析。中華民國營養學會雜誌 19 (4): 395-406.
  111. Lin, S.Y., Sheen, L.Y., and Tsai, S.J. 1994. Effect of microwave-heating on retention and composition of basil oil. Food Science 21 (1): 75-82.
  112. 林淑媛、沈立言、蔡順仁。1992。蒜、薑精油微膠囊在儲藏後之香味變化。中國農業化學會誌30 (4): 544-552.
  113. 沈立言、林淑媛、蔡順仁。1992。利用相分離法製備精油微膠囊及其性質之探討。中國農業化學會誌 30 (3): 307-320.
  114. 沈立言、林淑媛、蔡順仁。1992。不同精油添加量對於噴霧乾燥精油微膠囊品質之影響。食品科學 19 (2): 217-229.
  115. 沈立言、林淑媛、蔡順仁。1992。以氣相層析儀嗅聞法進行蒜及薑精油揮發性成分香氣之評估。中國農業化學會誌 30 (1): 14-24.
  116. 沈立言、林淑媛、蔡順仁。1991。不同精油含量之羅勒、蒜、薑精油微膠囊之製備及其精油成分在噴霧乾燥過程中之變化。食品科學18 (4): 344-355.
  117. 沈立言、蔡順仁。1991。薑、羅勒、蒜噴霧乾燥精油膠囊之製備及其性質之研究。中國農業化學會誌 29 (2): 226-237.
  118. Sheen, L.Y., Tsai Ou, Y.H., and Tsai, S.J. 1991. Flavor characteristic compounds found in the essential oil of Ocimum basilicum L. with sensory evaluation and statisticalanalysis. Journal of the Agricultural and Food Chemistry 39: 939-943. (SCI)
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