罗翊祯 | 台湾大学食品科技研究所

:::

职称	教授兼所长
姓名	罗翊祯
联络电话	02-3366-4123
电子邮件
学历	英国爱丁堡大学临床生化研究所博士 (2002)
研究专长	微生物基因工程、生物转换、营养与老化、基因修复

2023	Chiung-Jung Wen, Yen-Chun Koh, Yen-Chen Tung, Pin- Yu Ho, Shu-Chen Hsieh, Yi-Chen Lo, Jaw-Shiun Tsai, Min-Hsiung Pan (2023) Cross-sectional study: New approach for diagnostic identification of non-robust older adult. Mol. Nutr. Food Res.
2023	Yen-Chun Koh, Lee-Han Kuo, Ya-Yun Chang, Yen-Chen Tung, Yi-Chen Lo, and Min-Hsiung Pan* (2023) Modulatory Effect of Fermented Black Soybean and Adlay onGut Microbiota Contributes to Healthy Aging. Mol. Nutr. Food Res.
2022	Hai-Ching Pung, Wei-Sheng Lin, Yi-Chen Lo, Cheng-Chih Hsu, Chi-Tang Ho, Min-Hsiung Pan* (2022) Ulva prolifera polysaccharide exerts anti-obesity effects via upregulation of adiponectin expression and gut microbiota modulation iin high-fat diet-fed Q1 C57BL/6 mice. Journal of Food and Drug Analysis
2022	Yen-Tso Lai, Changwei Hsieh, Yi-Chen Lo, Bo-Kang Liou, Lin Hui Weh, Chih-Yao Hou and Kuan-Chen Cheng* (2022) Isolation and identification of aroma-producing non-saccharomyces yeast strains and the ecological characteristic comparison in wine making. LWT 154(3):112653.
2021	Chia-Ling Hsu, Yi-Chen Lo and Cheng-Fu Kao* (2021) H3K4 Methylation in Aging and Metabolism. Epigenome 5,14-43
2020	Shin Yen Chong, Sam Cutler, Jing-Jer Lin, Cheng-Hung Tsai, Huai-Kuang Tsai, Sue Biggins, Toshio Tsukiyama, Yi-Chen Lo* & Cheng-Fu Kao* (2020) H3K4 methylation at active genes mitigates transcription-replication conflicts during replication stress. Nat Commun 11:809
2020	Yi-Jui Liu, Yun-Ju Lai, Reuben Wang, Yi-Chen Lo, and Chun-Hui Chiu (2020) The effect of Thermal Processinng on the Saponin Profiles of Momordica Charantia L. Journal of Food Quality
2020	Wen-Chang Chang, Yin-Ting Hu, Qingrong Huang, *Shu-Chen Hsieh, Yuwen Ting (2020, Jan). Development of a topical applied functional food formulation: Adlay bran oil nanoemulgel. LWT-Food Science and Technology, 117,108619.
2019	Chun-Hui Chiu, Reuben Wang, Shasha Zhuang, Pei-Yin Lin, Yi-Chen Lo, Ting-Jang Lu* (2020) Biotransformation of mogrosides from Siraitia grosvenorii by Ganoderma lucidum mycelium and the purification of mogroside III E by macroporous resins. Journal of Food and Drug Analysis (In Press). (Corresponding Author)
2019	Shin Yen Chong, Hsin-Yi Chiang, Tzu-Hung Chen, Yi-Ju Liang, Yi-Chen Lo. Green tea extract promotes DNA repair in a yeast model. Sci. Rep. 9: 3842. (Corresponding Author)
2019	Reuben Wang, Yi-Chieh Chen, Yun-Ju Lai, Ting-Jang Lu, Shyue-Tsong Huang, Yi-Chen Lo. Dekkera bruxellensis, a beer yeast that specifically bioconverts mogroside extracts into the intense natural sweetener siamenoside I. Food Chemistry 276: 43-49. (Corresponding Author)
2018	Hsiao-Ping Kuo, Reuben Wang, Chiao-Ying Huang, Jinn-Tsyy Lai, Yi-Chen Lo, Shyue-Tsong Huang. Characterization of an extracellular β-glucosidase from Dekkera bruxellensis for resveratrol production. Journal of Food and Drug Analysis 26: 163-171. (Corresponding Author)
2018	Lung-Hsuan Chiang, Shih-Hsin Chen, Yi-Chen Lo, An-I Yeh. Estrogenic activity of yam via a yeast model and its effects on two cancer cell lines. Journal of Functional Foods 40: 86-92.
2017	Hsiao-Ping Kuo, Reuben Wang, Yi-Sheng Lin, Jinn-Tsyy Lai, Yi-Chen Lo, Shyue-Tsong Huang. Pilot scale repeated fed-batch fermentation processes of the wine yeast Dekkera bruxellensis for mass production of resveratrol from Polygonum cuspidatum. Bioresourse Technology 243: 986-993.
2016	Chia-Cheng Wei, Pei-Ling Yen, Shang-Tzen Chang, Pei-Ling Cheng, Yi-Chen Lo, Vivian Hsiu-Chuan Liao. Antioxidative Activities of Both Oleic Acid and Camellia tenuifolia Seed Oil Are Regulated by the Transcription Factor DAF-16/FOXO in Caenorhabditis elegans. PLoS ONE 11(6): e0157195.
2015	Reuben Wang, Pei-Yin Lin, Shyue-Tsong Huang, Chun-Hui Chiu, Ting-Jang Lu and Yi-Chen Lo. Hyperproduction of β‑Glucanase Exg1 Promotes the Bioconversion of Mogrosides in Saccharomyces cerevisiae Mutants Defective in Mannoprotein Deposition. J Agric Food Chem 63:10271-10279. (Corresponding Author）
2015	Hsiang-En Hsu, Tzu-Ning Liu, Chung-Shu Yeh, Tien-Hsien Chang, Yi-Chen Lo and Cheng-Fu Kao. Feedback control of Snf1 protein and its phosphorylation is necessary for adaptation to environmental stress. The Journal of Biological Chemistry 290:16786-16796. (Corresponding Author)
2013	Chun-Hui Chiu, Reuben Wang, Cho-Ching Lee, Yi-Chen Lo, and Ting-Jang Lu. Biotransformation of Mogrosides from Siraitia grosvenorii Swingle by Saccharomyces cerevisiae. J Agric Food Chem 61:7127-7134. (Corresponding Author）
2013	Shin Yen Chong, Meng-Ying Wu, and Yi-Chen Lo. Tangeretin Sensitizes SGS1-Deficient Cells by Inducing DNA Damage. J Agric Food Chem 61:6376-6382. (Corresponding Author)
2013	Chia-Yeh Lin, Wei-Chun Hsiao, Duncan Edward Wright, Chia-Ling Hsu, Yi-Chen Lo, Guoo-Shyng Wang Hsu, Cheng-Fu Kao. Resveratrol activates the histone H2B ubiquitin ligase, RNF20, in MD A-MB-231 breast cancer cells. Journal of Functional Foods 5: 790-800.
2013	Andy Chi-Lung Lee, Wei-Chun Hsiao, Duncan Edward Wright, Shin Yen Chong, Siew Keng Leow, Chi-Tang Ho, Cheng-Fu Kao, Yi-Chen Lo. Induction of GADD45a expression contributes to the anti-proliferative effects of polymethoxyflavones on colorectal cancer cells . Journal of Functional Foods 5: 616-624. (Corresponding Author)
2013	Kuan-I Chen, Yi-Chen Lo, Nan-Wei Su, Cheng-Chun Chou, and Kuan-Chen Cheng. Enrichment of isoflavone aglycones in black soymilk by using coffee pulp as an immobilizer for beta-glucosidase. Food Chem 139:79-85.
2013	Yu-Fei Chen, Ming-Lun Chiang, Cheng-Chun Chou and Yi-Chen Lo. Enhancing the antitumor cell proliferation and Cu2+ -chelating effects of black soybeans through fermentation with Aspergillus awamori. Journal of Bioscience and Bioengineering 115: 400-404. (Corresponding Author)
2012	Kuan-I Chen, Yi-Chen Lo, Nan-Wei Su, Cheng-Chun Chou, Kuan-Chen Cheng. Enrichment of Two Isoflavone Aglycones in Black Soymilk by Immobilized β-Glucosidase on Solid Carriers. J Agric Food Chem 60 (51):12540-12546.
2012	Hong-Jhang Chen, Yi-Chen Lo, Wenchang Chiang. Inhibitory effects of adlay bran (Coix lachryma-jobi L. var. ma-yuen Stapf) on chemical mediator release and cytokine production in rat basophilic leukemia cells. J. Ethnopharmacol 141:119-127.
2011	Grace S. Shieh, Chin-Hua Pan, Jia-Hong Wu, Yun-Ju Sun, Chia-Chang Wang, Wei-Chun Hsiao, Chia-Yeh Lin, Luh Tung, Tien-Hsien Chang, Alastair B. Fleming, Cory Hillyer, Yi-Chen Lo, Shelley L. Berger, Mary Ann Osley and Cheng-Fu Kao. H2B ubiquitylation is part of chromatin architecture that marks exon-intron structure in budding yeast BMC Genomics 12: 627.
2009	Toyoko Tsukuda, Yi-Chen Lo, Sanchita Krishna, Rosa Sterk, Mary Ann Osley, Jac A. Nickoloff. INO80-dependent chromatin remodeling regulates early and late stages of mitotic homologous recombination DNA. Repair 8: 360–369. (*equal contribution)
2008	Grace S Shieh, Chung-Ming Chen, Ching-Yun Yu, Juiling Huang, Woei-Fuh Wang, Yi-Chen Lo. Inferring transcriptional compensation interactions in yeast via stepwise structure equation modeling. BMC Bioinformatics 9:134-143.
2007	Sanchita Krishna, Brant M. Wagenera, Hui Ping Liua, Yi-Chen Lo, Rosa Sterka, John H.J. Petrini, Jac A. Nickoloff. Mre11 and Ku regulation of double-strand break repair by gene conversion and break-induced replication. DNA repair 6: 797-808.
2006	Yi-Chen Lo, Kimberly S. Paffet, Or Amit, Jennifer A. Clikeman, Rosa Sterk, Mark A. Brenneman and Jac A. Nickoloff. Sgs1 Regulation of Gene Conversion Tract Lengths and Crossovers is Independent of ATP Hydrolysis. Molecular and Cellular Biology 26: 4086-4094.
2005	Lo, Y. C., Kurtz, R. B. & Nickoloff, J. A. Analysis of chromosome/allele loss in genetically unstable yeast by quantitative real-time PCR. Biotechniques 38, 685-690.
2000	Y-C. Lo, S. Mackenzie, A.F. Howie, D.K. Apps, J.I. Mason, B.C. Williams and S.D. Morley. Properties of an adrenal medullary protein immuno-related to steroidogenic acute regulatory (StAR) protein. Endocrine Research 26 (4):737-748.
1999	Y-C. Lo, C.E. Gomez-Sanchez, C.J. Kenyon, J.I. Mason and B.C. Williams. Effects of dietary sodium on aldosterone synthase, 11b-hydroxylase and 3b-hydroxysteroid dehydrogenase expression in pregnant and foetal wistar rats. Molecular Steroidogenesis Frontiers Sciences Series No. 29:349-350.
1998	Y-C. Lo, L.Brett, C.J. Kenyon, S.D.Morley, J.I. Mason and B.C. Williams. StAR protein is expressed in both medulla and cortex of the bovine and rat adrenal gland. Endocrine Research 24(3&4): 559-563.
1996	Y.C. Lo and Y.F. Lu. Effect of deep frying oil and cholesterol on fatty acid composition in rat tissues. Food Science 23(2): 276-284.
1995	Y.C. Lo and Y.F. Lu. Effect of deep frying oil given with and without dietary cholesterol on lipid metabolism in rats. Nutrition Research 15(12):1783-1792.
1994	C.Y. Tang, H.L. Wu, Y.C. Lo and Y.F. Lu. Investigation on the contents of cholesterol oxides in commercial dried fishery products. Food Science 21(2): 107-113.

张心柔、林书妍、陈柏安、吕廷璋、罗翊祯。探讨以艾尔及拉格酿酒酵母 (Saccharomyces菌属) 发酵酒精型包种茶之香气组成。2024台湾质谱学会第20届学术研讨会。2024年06月。台南，台湾。
李湘怡、罗翊祯。Pantoea vagans M17 之群体感应调节对运动性和生物膜形成的影响。台湾农业化学会113年度研讨会暨第62次会员大会。2024年06月。台北，台湾。
黄筱婷、罗翊祯。有机酸对 Enterobacter mori FS08 运动性及生物膜形成的影响。台湾农业化学会113年度研讨会暨第62次会员大会。2024年06月。台北，台湾。
沈恩池、罗翊祯。探讨食品病原菌和分离自截切小黄瓜之菌株共培养后生物膜的形成。台湾农业化学会113年度研讨会暨第62次会员大会。2024年06月。台北，台湾。
邓元睿、苏沛蓁、罗翊祯。以酵母菌生物合成葫芦素B. 2024台湾保健食品学会年会暨国际学术研讨会。2024年3月。高雄。台湾。
张语倢、邓元睿、罗翊祯。以酵母菌生物合成芳樟醇.2024台湾保健食品学会年会暨国际学术研讨会。2024年3月。高雄。台湾。
苏沛蓁、邓元睿、张心柔、吕廷璋、罗翊祯。利用酿酒酵母菌生合成葫芦素B前驱物。台湾农业化学会112年度研讨会暨第61次会员大会口头论文竞赛决赛。2023年06月。台北，台湾。
林琦芳、王如邦、罗翊祯。探讨醣基水解酶对罗汉果皂苷的转醣作用。台湾农业化学会112年度研讨会暨第61次会员大会口头论文竞赛决赛。2023年06月。台北，台湾。
李奕慧、邓婷云、吴奕蓉、罗翊祯。探讨 L-苹果酸对 Pantoea vagans M17 表面移行和生物膜形成能力的影响。台湾农业化学会112年度研讨会暨第61次会员大会口头论文竞赛决赛。2023年06月。台北，台湾。
邓元睿、苏沛蓁、林琦芳、张语倢、罗翊祯。罗汉果皂苷甜味剂。台湾保健食品学会，保健食品机能素材开发研究奖。2023年03月。台北，台湾。
王姿羿、罗翊祯。利用乳酸菌及酵母菌之酵素转换人参皂苷。台湾农业化学会111年度研讨会暨第60次会员大会。2022年06月。台北，台湾。
顾子欣、罗翊祯。小黄瓜成分诱发分离菌株Enterobacter sp. FS08之趋化泳动。台湾农业化学会111年度研讨会暨第60次会员大会。2022年06月。台北，台湾。
邓婷云、罗翊祯。Pantoea vagans M17之表面移行及生物膜与截切香瓜腐败有关。台湾农业化学会111年度研讨会暨第60次会员大会。2022年06月。台北，台湾。
张心柔*、林书妍、陈柏安、吕廷璋、高承福、罗翊祯*。Biotransformation of paochong tea infusion using brewing yeast. 2020 台湾酵母菌生物学会议。海报张贴 [线上]。2022年01月。台北，台湾。
邓元睿*、储皖贞、邱群惠、高承福、罗翊祯*。Biosynthesis of cucurbitane-type triterpenoid precursors in engineered Saccharomyces cerevisiae. 2020 台湾酵母菌生物学会议。海报张贴 [线上]。2022年01月。台北，台湾。
郭思妤*、林稚杰、吕廷璋、罗翊祯*。Enzymatic transglycosylation of Saccharomyces cerevisiae EXG1 to synthesize laminarin-derived oligosaccharides. 2020 台湾酵母菌生物学会议。海报张贴 [线上]。2022年01月。台北，台湾。
张淑颖*、吴奕蓉*、姚颖君、吕廷璋、罗翊祯*. Effect of Pantoea spp. on the quality of fresh-cut melons. 2021年台湾食品科学技术学会第51次会员大会暨科技整合与食品创新研讨会。2021年 11 月。台北，台湾。

Reuben Wang, Chun-Hui Chiu, Ting-Jang Lu, and Yi-Chen Lo＊,. Biotransformation of Mogrosides. . Sweeteners, Reference Series in Phytochemistry, (ISBN: DOI 10.1007/978-3-319-26478-3_13-1). Springer International Publishing AG. 2017.

计画期间

1. Yi-Chen Lo, Ting-Jang Lu, Ruben Wang. 2021. Method for bioconversion of mogroside extracts into siamenoside I. United States Patent 11,180,789. Patent term: Nov. 23, 2021 – Dec. 10, 2039.
2. 罗翊祯、吕廷璋、王如邦。2020。将罗汉果皂苷萃取物生物转化为赛门苷I之方法。中华民国专利公报，证书号数I711385。专利权期间: 2020年12月1日至2039年9月25日。

食品营养学 (Food Nutrition)
食品微生物基因体 (Food Microbial Genomics)
食品微生物 (Food Microbiology)
微生物基因工程学 (Microbial Genetic Engineering)
脂质代谢(lipid metabolism)
营养与遗传(Nutrition and Genetics, Prenatal Programming)
分子内分泌学( Molecular Endocrinology)
基因修复 (DNA repair)
细胞周期的调节 (Cell cycle regulation)

辅仁大学食品营养系营养组学士 (1991)
辅仁大学营养脂质代谢硕士 (1993)
英国爱丁堡大学临床生化研究所博士 (2002)

教授兼所长, 台湾大学食品科技研究所 8/ 2024-现在
教授, 台湾大学食品科技研究所 8/2019-8/ 2024
副教授, 台湾大学食品科技研究所 8/ 2014-8/ 2019
助理教授, 台湾大学食品科技研究所 2/ 2008-8/ 2014
博士后研究员, 中央研究院细胞与个体生物学研究所 1/ 2007-1/2008
Associate Scientist, 美国新墨西哥州大学分子遗传暨微生物学系 4/2005 –11/2006
博士后研究员, 美国新墨西哥州大学分子遗传暨微生物学系 3/2002 –3/2005
讲师, 台中中台医事技术大学 8/1993 – 7/1997
在职短期进修, 新竹食品工业研究所食品分析组 7/1995 – 8/1995
讲师, 台中市卫生局举办之社区营养与食品卫生讲座 9/1994 – 2/1995
实习生, 台北市食品药物检验局 7/1993 – 8/1993
实习生, 台北市国泰医院营养室 7/1990 – 8/1990

教育部奖学金 1991-1993
Overseas Research Students Award in the United Kingdom 1998-2002
Wellcome Trust Travel grant for The ADRENAL 2000 and ENDO 2000 conferences, Toronto Canada 16^th - 26^th June,2000

台大食品科技研究所