Yi Chen Lo | 臺灣大學食品科技研究所

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職稱	教授兼所長
姓名	羅翊禎
聯絡電話	02-3366-4123
電子郵件
學歷	英國愛丁堡大學臨床生化研究所博士 (2002)
研究專長	微生物基因工程、生物轉換、營養與老化、基因修復

2023	Chiung-Jung Wen, Yen-Chun Koh, Yen-Chen Tung, Pin- Yu Ho, Shu-Chen Hsieh, Yi-Chen Lo, Jaw-Shiun Tsai, Min-Hsiung Pan (2023) Cross-sectional study: New approach for diagnostic identification of non-robust older adult. Mol. Nutr. Food Res.
2023	Yen-Chun Koh, Lee-Han Kuo, Ya-Yun Chang, Yen-Chen Tung, Yi-Chen Lo, and Min-Hsiung Pan* (2023) Modulatory Effect of Fermented Black Soybean and Adlay onGut Microbiota Contributes to Healthy Aging. Mol. Nutr. Food Res.
2022	Hai-Ching Pung, Wei-Sheng Lin, Yi-Chen Lo, Cheng-Chih Hsu, Chi-Tang Ho, Min-Hsiung Pan* (2022) Ulva prolifera polysaccharide exerts anti-obesity effects via upregulation of adiponectin expression and gut microbiota modulation iin high-fat diet-fed Q1 C57BL/6 mice. Journal of Food and Drug Analysis
2022	Yen-Tso Lai, Changwei Hsieh, Yi-Chen Lo, Bo-Kang Liou, Lin Hui Weh, Chih-Yao Hou and Kuan-Chen Cheng* (2022) Isolation and identification of aroma-producing non-saccharomyces yeast strains and the ecological characteristic comparison in wine making. LWT 154(3):112653.
2021	Chia-Ling Hsu, Yi-Chen Lo and Cheng-Fu Kao* (2021) H3K4 Methylation in Aging and Metabolism. Epigenome 5,14-43
2020	Shin Yen Chong, Sam Cutler, Jing-Jer Lin, Cheng-Hung Tsai, Huai-Kuang Tsai, Sue Biggins, Toshio Tsukiyama, Yi-Chen Lo* & Cheng-Fu Kao* (2020) H3K4 methylation at active genes mitigates transcription-replication conflicts during replication stress. Nat Commun 11:809
2020	Yi-Jui Liu, Yun-Ju Lai, Reuben Wang, Yi-Chen Lo, and Chun-Hui Chiu (2020) The effect of Thermal Processinng on the Saponin Profiles of Momordica Charantia L. Journal of Food Quality
2020	Wen-Chang Chang, Yin-Ting Hu, Qingrong Huang, *Shu-Chen Hsieh, Yuwen Ting (2020, Jan). Development of a topical applied functional food formulation: Adlay bran oil nanoemulgel. LWT-Food Science and Technology, 117,108619.
2019	Chun-Hui Chiu, Reuben Wang, Shasha Zhuang, Pei-Yin Lin, Yi-Chen Lo, Ting-Jang Lu* (2020) Biotransformation of mogrosides from Siraitia grosvenorii by Ganoderma lucidum mycelium and the purification of mogroside III E by macroporous resins. Journal of Food and Drug Analysis (In Press). (Corresponding Author)
2019	Shin Yen Chong, Hsin-Yi Chiang, Tzu-Hung Chen, Yi-Ju Liang, Yi-Chen Lo. Green tea extract promotes DNA repair in a yeast model. Sci. Rep. 9: 3842. (Corresponding Author)
2019	Reuben Wang, Yi-Chieh Chen, Yun-Ju Lai, Ting-Jang Lu, Shyue-Tsong Huang, Yi-Chen Lo. Dekkera bruxellensis, a beer yeast that specifically bioconverts mogroside extracts into the intense natural sweetener siamenoside I. Food Chemistry 276: 43-49. (Corresponding Author)
2018	Hsiao-Ping Kuo, Reuben Wang, Chiao-Ying Huang, Jinn-Tsyy Lai, Yi-Chen Lo, Shyue-Tsong Huang. Characterization of an extracellular β-glucosidase from Dekkera bruxellensis for resveratrol production. Journal of Food and Drug Analysis 26: 163-171. (Corresponding Author)
2018	Lung-Hsuan Chiang, Shih-Hsin Chen, Yi-Chen Lo, An-I Yeh. Estrogenic activity of yam via a yeast model and its effects on two cancer cell lines. Journal of Functional Foods 40: 86-92.
2017	Hsiao-Ping Kuo, Reuben Wang, Yi-Sheng Lin, Jinn-Tsyy Lai, Yi-Chen Lo, Shyue-Tsong Huang. Pilot scale repeated fed-batch fermentation processes of the wine yeast Dekkera bruxellensis for mass production of resveratrol from Polygonum cuspidatum. Bioresourse Technology 243: 986-993.
2016	Chia-Cheng Wei, Pei-Ling Yen, Shang-Tzen Chang, Pei-Ling Cheng, Yi-Chen Lo, Vivian Hsiu-Chuan Liao. Antioxidative Activities of Both Oleic Acid and Camellia tenuifolia Seed Oil Are Regulated by the Transcription Factor DAF-16/FOXO in Caenorhabditis elegans. PLoS ONE 11(6): e0157195.
2015	Reuben Wang, Pei-Yin Lin, Shyue-Tsong Huang, Chun-Hui Chiu, Ting-Jang Lu and Yi-Chen Lo. Hyperproduction of β‑Glucanase Exg1 Promotes the Bioconversion of Mogrosides in Saccharomyces cerevisiae Mutants Defective in Mannoprotein Deposition. J Agric Food Chem 63:10271-10279. (Corresponding Author）
2015	Hsiang-En Hsu, Tzu-Ning Liu, Chung-Shu Yeh, Tien-Hsien Chang, Yi-Chen Lo and Cheng-Fu Kao. Feedback control of Snf1 protein and its phosphorylation is necessary for adaptation to environmental stress. The Journal of Biological Chemistry 290:16786-16796. (Corresponding Author)
2013	Chun-Hui Chiu, Reuben Wang, Cho-Ching Lee, Yi-Chen Lo, and Ting-Jang Lu. Biotransformation of Mogrosides from Siraitia grosvenorii Swingle by Saccharomyces cerevisiae. J Agric Food Chem 61:7127-7134. (Corresponding Author）
2013	Shin Yen Chong, Meng-Ying Wu, and Yi-Chen Lo. Tangeretin Sensitizes SGS1-Deficient Cells by Inducing DNA Damage. J Agric Food Chem 61:6376-6382. (Corresponding Author)
2013	Chia-Yeh Lin, Wei-Chun Hsiao, Duncan Edward Wright, Chia-Ling Hsu, Yi-Chen Lo, Guoo-Shyng Wang Hsu, Cheng-Fu Kao. Resveratrol activates the histone H2B ubiquitin ligase, RNF20, in MD A-MB-231 breast cancer cells. Journal of Functional Foods 5: 790-800.
2013	Andy Chi-Lung Lee, Wei-Chun Hsiao, Duncan Edward Wright, Shin Yen Chong, Siew Keng Leow, Chi-Tang Ho, Cheng-Fu Kao, Yi-Chen Lo. Induction of GADD45a expression contributes to the anti-proliferative effects of polymethoxyflavones on colorectal cancer cells . Journal of Functional Foods 5: 616-624. (Corresponding Author)
2013	Kuan-I Chen, Yi-Chen Lo, Nan-Wei Su, Cheng-Chun Chou, and Kuan-Chen Cheng. Enrichment of isoflavone aglycones in black soymilk by using coffee pulp as an immobilizer for beta-glucosidase. Food Chem 139:79-85.
2013	Yu-Fei Chen, Ming-Lun Chiang, Cheng-Chun Chou and Yi-Chen Lo. Enhancing the antitumor cell proliferation and Cu2+ -chelating effects of black soybeans through fermentation with Aspergillus awamori. Journal of Bioscience and Bioengineering 115: 400-404. (Corresponding Author)
2012	Kuan-I Chen, Yi-Chen Lo, Nan-Wei Su, Cheng-Chun Chou, Kuan-Chen Cheng. Enrichment of Two Isoflavone Aglycones in Black Soymilk by Immobilized β-Glucosidase on Solid Carriers. J Agric Food Chem 60 (51):12540-12546.
2012	Hong-Jhang Chen, Yi-Chen Lo, Wenchang Chiang. Inhibitory effects of adlay bran (Coix lachryma-jobi L. var. ma-yuen Stapf) on chemical mediator release and cytokine production in rat basophilic leukemia cells. J. Ethnopharmacol 141:119-127.
2011	Grace S. Shieh, Chin-Hua Pan, Jia-Hong Wu, Yun-Ju Sun, Chia-Chang Wang, Wei-Chun Hsiao, Chia-Yeh Lin, Luh Tung, Tien-Hsien Chang, Alastair B. Fleming, Cory Hillyer, Yi-Chen Lo, Shelley L. Berger, Mary Ann Osley and Cheng-Fu Kao. H2B ubiquitylation is part of chromatin architecture that marks exon-intron structure in budding yeast BMC Genomics 12: 627.
2009	Toyoko Tsukuda, Yi-Chen Lo, Sanchita Krishna, Rosa Sterk, Mary Ann Osley, Jac A. Nickoloff. INO80-dependent chromatin remodeling regulates early and late stages of mitotic homologous recombination DNA. Repair 8: 360–369. (*equal contribution)
2008	Grace S Shieh, Chung-Ming Chen, Ching-Yun Yu, Juiling Huang, Woei-Fuh Wang, Yi-Chen Lo. Inferring transcriptional compensation interactions in yeast via stepwise structure equation modeling. BMC Bioinformatics 9:134-143.
2007	Sanchita Krishna, Brant M. Wagenera, Hui Ping Liua, Yi-Chen Lo, Rosa Sterka, John H.J. Petrini, Jac A. Nickoloff. Mre11 and Ku regulation of double-strand break repair by gene conversion and break-induced replication. DNA repair 6: 797-808.
2006	Yi-Chen Lo, Kimberly S. Paffet, Or Amit, Jennifer A. Clikeman, Rosa Sterk, Mark A. Brenneman and Jac A. Nickoloff. Sgs1 Regulation of Gene Conversion Tract Lengths and Crossovers is Independent of ATP Hydrolysis. Molecular and Cellular Biology 26: 4086-4094.
2005	Lo, Y. C., Kurtz, R. B. & Nickoloff, J. A. Analysis of chromosome/allele loss in genetically unstable yeast by quantitative real-time PCR. Biotechniques 38, 685-690.
2000	Y-C. Lo, S. Mackenzie, A.F. Howie, D.K. Apps, J.I. Mason, B.C. Williams and S.D. Morley. Properties of an adrenal medullary protein immuno-related to steroidogenic acute regulatory (StAR) protein. Endocrine Research 26 (4):737-748.
1999	Y-C. Lo, C.E. Gomez-Sanchez, C.J. Kenyon, J.I. Mason and B.C. Williams. Effects of dietary sodium on aldosterone synthase, 11b-hydroxylase and 3b-hydroxysteroid dehydrogenase expression in pregnant and foetal wistar rats. Molecular Steroidogenesis Frontiers Sciences Series No. 29:349-350.
1998	Y-C. Lo, L.Brett, C.J. Kenyon, S.D.Morley, J.I. Mason and B.C. Williams. StAR protein is expressed in both medulla and cortex of the bovine and rat adrenal gland. Endocrine Research 24(3&4): 559-563.
1996	Y.C. Lo and Y.F. Lu. Effect of deep frying oil and cholesterol on fatty acid composition in rat tissues. Food Science 23(2): 276-284.
1995	Y.C. Lo and Y.F. Lu. Effect of deep frying oil given with and without dietary cholesterol on lipid metabolism in rats. Nutrition Research 15(12):1783-1792.
1994	C.Y. Tang, H.L. Wu, Y.C. Lo and Y.F. Lu. Investigation on the contents of cholesterol oxides in commercial dried fishery products. Food Science 21(2): 107-113.

張心柔、林書妍、陳柏安、呂廷璋、羅翊禎。探討以艾爾及拉格釀酒酵母 (Saccharomyces菌屬) 發酵酒精型包種茶之香氣組成。2024台灣質譜學會第20屆學術研討會。2024年06月。臺南，臺灣。
李湘怡、羅翊禎。Pantoea vagans M17 之群體感應調節對運動性和生物膜形成的影響。台灣農業化學會113年度研討會暨第62次會員大會。2024年06月。臺北，臺灣。
黃筱婷、羅翊禎。有機酸對 Enterobacter mori FS08 運動性及生物膜形成的影響。台灣農業化學會113年度研討會暨第62次會員大會。2024年06月。臺北，臺灣。
沈恩池、羅翊禎。探討食品病原菌和分離自截切小黃瓜之菌株共培養後生物膜的形成。台灣農業化學會113年度研討會暨第62次會員大會。2024年06月。臺北，臺灣。
鄧元睿、蘇沛蓁、羅翊禎。以酵母菌生物合成葫蘆素B. 2024台灣保健食品學會年會暨國際學術研討會。2024年3月。高雄。台灣。
張語倢、鄧元睿、羅翊禎。以酵母菌生物合成芳樟醇.2024台灣保健食品學會年會暨國際學術研討會。2024年3月。高雄。台灣。
蘇沛蓁、鄧元睿、張心柔、呂廷璋、羅翊禎。利用釀酒酵母菌生合成葫蘆素B前驅物。台灣農業化學會112年度研討會暨第61次會員大會口頭論文競賽決賽。2023年06月。臺北，臺灣。
林琦芳、王如邦、羅翊禎。探討醣基水解酶對羅漢果皂苷的轉醣作用。台灣農業化學會112年度研討會暨第61次會員大會口頭論文競賽決賽。2023年06月。臺北，臺灣。
李奕慧、鄧婷云、吳奕蓉、羅翊禎。探討 L-蘋果酸對 Pantoea vagans M17 表面移行和生物膜形成能力的影響。台灣農業化學會112年度研討會暨第61次會員大會口頭論文競賽決賽。2023年06月。臺北，臺灣。
鄧元睿、蘇沛蓁、林琦芳、張語倢、羅翊禎。羅漢果皂苷甜味劑。台灣保健食品學會，保健食品機能素材開發研究獎。2023年03月。臺北，臺灣。
王姿羿、羅翊禎。利用乳酸菌及酵母菌之酵素轉換人參皂苷。台灣農業化學會111年度研討會暨第60次會員大會。2022年06月。臺北，臺灣。
顧子欣、羅翊禎。小黃瓜成分誘發分離菌株Enterobacter sp. FS08之趨化泳動。台灣農業化學會111年度研討會暨第60次會員大會。2022年06月。臺北，臺灣。
鄧婷云、羅翊禎。Pantoea vagans M17之表面移行及生物膜與截切香瓜腐敗有關。台灣農業化學會111年度研討會暨第60次會員大會。2022年06月。臺北，臺灣。
張心柔*、林書妍、陳柏安、呂廷璋、高承福、羅翊禎*。Biotransformation of paochong tea infusion using brewing yeast. 2020 臺灣酵母菌生物學會議。海報張貼 [線上]。2022年01月。臺北，臺灣。
鄧元睿*、儲皖貞、邱群惠、高承福、羅翊禎*。Biosynthesis of cucurbitane-type triterpenoid precursors in engineered Saccharomyces cerevisiae. 2020 臺灣酵母菌生物學會議。海報張貼 [線上]。2022年01月。臺北，臺灣。
郭思妤*、林稚傑、呂廷璋、羅翊禎*。Enzymatic transglycosylation of Saccharomyces cerevisiae EXG1 to synthesize laminarin-derived oligosaccharides. 2020 臺灣酵母菌生物學會議。海報張貼 [線上]。2022年01月。臺北，臺灣。
張淑穎*、吳奕蓉*、姚穎君、呂廷璋、羅翊禎*. Effect of Pantoea spp. on the quality of fresh-cut melons. 2021年臺灣食品科學技術學會第51次會員大會暨科技整合與食品創新研討會。2021年 11 月。臺北，臺灣。

Reuben Wang, Chun-Hui Chiu, Ting-Jang Lu, and Yi-Chen Lo＊,. Biotransformation of Mogrosides. . Sweeteners, Reference Series in Phytochemistry, (ISBN: DOI 10.1007/978-3-319-26478-3_13-1). Springer International Publishing AG. 2017.

計畫期間

1. Yi-Chen Lo, Ting-Jang Lu, Ruben Wang. 2021. Method for bioconversion of mogroside extracts into siamenoside I. United States Patent 11,180,789. Patent term: Nov. 23, 2021 – Dec. 10, 2039.
2. 羅翊禎、呂廷璋、王如邦。2020。將羅漢果皂苷萃取物生物轉化為賽門苷I之方法。中華民國專利公報，證書號數I711385。專利權期間: 2020年12月1日至2039年9月25日。

食品營養學 (Food Nutrition)
食品微生物基因體 (Food Microbial Genomics)
食品微生物 (Food Microbiology)
微生物基因工程學 (Microbial Genetic Engineering)
脂質代謝(lipid metabolism)
營養與遺傳(Nutrition and Genetics, Prenatal Programming)
分子內分泌學( Molecular Endocrinology)
基因修復 (DNA repair)
細胞週期的調節 (Cell cycle regulation)

輔仁大學食品營養系營養組學士 (1991)
輔仁大學營養脂質代謝碩士 (1993)
英國愛丁堡大學臨床生化研究所博士 (2002)

教授兼所長, 台灣大學食品科技研究所 8/ 2024-現在
教授, 台灣大學食品科技研究所 8/2019-8/ 2024
副教授, 台灣大學食品科技研究所 8/ 2014-8/ 2019
助理教授, 台灣大學食品科技研究所 2/ 2008-8/ 2014
博士後研究員, 中央研究院細胞與個體生物學研究所 1/ 2007-1/2008
Associate Scientist, 美國新墨西哥州大學分子遺傳暨微生物學系 4/2005 –11/2006
博士後研究員, 美國新墨西哥州大學分子遺傳暨微生物學系 3/2002 –3/2005
講師, 台中中台醫事技術大學 8/1993 – 7/1997
在職短期進修, 新竹食品工業研究所食品分析組 7/1995 – 8/1995
講師, 台中市衛生局舉辦之社區營養與食品衛生講座 9/1994 – 2/1995
實習生, 台北市食品藥物檢驗局 7/1993 – 8/1993
實習生, 台北市國泰醫院營養室 7/1990 – 8/1990

教育部獎學金 1991-1993
Overseas Research Students Award in the United Kingdom 1998-2002
Wellcome Trust Travel grant for The ADRENAL 2000 and ENDO 2000 conferences, Toronto Canada 16^th - 26^th June,2000

台大食品科技研究所