台大食品科技研究所

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羅 翊禎
專任教師
職稱 教授
姓名 羅 翊禎
聯絡電話 02-3366-4123
電子郵件 loyichen@ntu.edu.tw
學歷 英國愛丁堡大學臨床生化研究所博士 (2002)
研究專長 微生物基因工程、 生物轉換、營養與老化、基因修復
個人網址 http://loyichen.org/index.html/
2019 Chun-Hui Chiu, Reuben Wang, Shasha Zhuang, Pei-Yin Lin, Yi-Chen Lo, Ting-Jang Lu. Biotransformation of mogrosides from Siraitia grosvenorii by Ganoderma lucidum mycelium and the purification of mogroside III E by macroporous resins. Journal of Food and Drug Analysis (In Press). (Corresponding Author)
2019 Shin Yen Chong, Hsin-Yi Chiang, Tzu-Hung Chen, Yi-Ju Liang, Yi-Chen Lo. Green tea extract promotes DNA repair in a yeast model. Sci. Rep. 9: 3842. (Corresponding Author)
2019 Reuben Wang, Yi-Chieh Chen, Yun-Ju Lai, Ting-Jang Lu, Shyue-Tsong Huang, Yi-Chen Lo. Dekkera bruxellensis, a beer yeast that specifically bioconverts mogroside extracts into the intense natural sweetener siamenoside I. Food Chemistry 276: 43-49. (Corresponding Author)
2018 Hsiao-Ping Kuo, Reuben Wang, Chiao-Ying Huang, Jinn-Tsyy Lai, Yi-Chen Lo, Shyue-Tsong Huang. Characterization of an extracellular β-glucosidase from Dekkera bruxellensis for resveratrol production. Journal of Food and Drug Analysis 26: 163-171. (Corresponding Author)
2018 Lung-Hsuan Chiang, Shih-Hsin Chen, Yi-Chen Lo, An-I Yeh. Estrogenic activity of yam via a yeast model and its effects on two cancer cell lines. Journal of Functional Foods 40: 86-92.
2017 Hsiao-Ping Kuo, Reuben Wang, Yi-Sheng Lin, Jinn-Tsyy Lai, Yi-Chen Lo, Shyue-Tsong Huang. Pilot scale repeated fed-batch fermentation processes of the wine yeast Dekkera bruxellensis for mass production of resveratrol from Polygonum cuspidatum. Bioresourse Technology 243: 986-993.
2016 Chia-Cheng Wei, Pei-Ling Yen, Shang-Tzen Chang, Pei-Ling Cheng, Yi-Chen Lo, Vivian Hsiu-Chuan Liao. Antioxidative Activities of Both Oleic Acid and Camellia tenuifolia Seed Oil Are Regulated by the Transcription Factor DAF-16/FOXO in Caenorhabditis elegans. PLoS ONE 11(6): e0157195.
2015 Reuben Wang, Pei-Yin Lin, Shyue-Tsong Huang, Chun-Hui Chiu, Ting-Jang Lu and Yi-Chen Lo. Hyperproduction of β‑Glucanase Exg1 Promotes the Bioconversion of Mogrosides in Saccharomyces cerevisiae Mutants Defective in Mannoprotein Deposition. J Agric Food Chem 63:10271-10279. (Corresponding Author) 
2015 Hsiang-En Hsu,  Tzu-Ning Liu,  Chung-Shu Yeh,  Tien-Hsien Chang,  Yi-Chen Lo and  Cheng-Fu Kao. Feedback control of Snf1 protein and its phosphorylation is necessary for adaptation to environmental stress. The Journal of Biological Chemistry 290:16786-16796. (Corresponding Author)
2013 Chun-Hui Chiu, Reuben Wang, Cho-Ching Lee, Yi-Chen Lo, and Ting-Jang Lu. Biotransformation of Mogrosides from Siraitia grosvenorii Swingle by Saccharomyces cerevisiae. J Agric Food Chem 61:7127-7134. (Corresponding Author)
2013 Shin Yen Chong, Meng-Ying Wu, and Yi-Chen Lo. Tangeretin Sensitizes SGS1-Deficient Cells by Inducing DNA Damage.  J Agric Food Chem 61:6376-6382. (Corresponding Author)
2013 Chia-Yeh Lin, Wei-Chun Hsiao, Duncan Edward Wright, Chia-Ling Hsu, Yi-Chen Lo, Guoo-Shyng Wang Hsu, Cheng-Fu Kao. Resveratrol activates the histone H2B ubiquitin ligase, RNF20, in MD A-MB-231 breast cancer cells. Journal of Functional Foods 5: 790-800.
2013 Andy Chi-Lung Lee, Wei-Chun Hsiao, Duncan Edward Wright, Shin Yen Chong, Siew Keng Leow, Chi-Tang Ho, Cheng-Fu Kao, Yi-Chen Lo. Induction of GADD45a expression contributes to the anti-proliferative effects of polymethoxyflavones on colorectal cancer cells . Journal of Functional Foods 5: 616-624. (Corresponding Author)
2013 Kuan-I Chen, Yi-Chen Lo, Nan-Wei Su, Cheng-Chun Chou, and Kuan-Chen Cheng. Enrichment of isoflavone aglycones in black soymilk by using coffee pulp as an immobilizer for beta-glucosidase. Food Chem 139:79-85.
2013 Yu-Fei Chen, Ming-Lun Chiang, Cheng-Chun Chou and Yi-Chen Lo. Enhancing the antitumor cell proliferation and Cu2+ -chelating effects of black soybeans through fermentation with Aspergillus awamori. Journal of Bioscience and Bioengineering 115: 400-404. (Corresponding Author)
2012 Kuan-I Chen, Yi-Chen Lo, Nan-Wei Su, Cheng-Chun Chou, Kuan-Chen Cheng. Enrichment of Two Isoflavone Aglycones in Black Soymilk by Immobilized β-Glucosidase on Solid Carriers.  J Agric Food Chem 60 (51):12540-12546.
2012 Hong-Jhang Chen, Yi-Chen Lo, Wenchang Chiang. Inhibitory effects of adlay bran (Coix lachryma-jobi L. var. ma-yuen Stapf) on chemical mediator release and cytokine production in rat basophilic leukemia cells. J.  Ethnopharmacol 141:119-127.
2011 Grace S. Shieh, Chin-Hua Pan, Jia-Hong Wu, Yun-Ju Sun, Chia-Chang Wang, Wei-Chun Hsiao, Chia-Yeh Lin, Luh Tung, Tien-Hsien Chang, Alastair B. Fleming, Cory Hillyer, Yi-Chen Lo, Shelley L. Berger, Mary Ann Osley and Cheng-Fu Kao. H2B ubiquitylation is part of chromatin architecture that marks exon-intron structure in budding yeast BMC Genomics 12: 627.
2009 *Toyoko Tsukuda, *Yi-Chen Lo, Sanchita Krishna, Rosa Sterk, Mary Ann Osley, Jac A. Nickoloff. INO80-dependent chromatin remodeling regulates early and late stages of mitotic homologous recombination DNA. Repair 8: 360–369. (*equal contribution)
2008 Grace S Shieh, Chung-Ming Chen, Ching-Yun Yu, Juiling Huang, Woei-Fuh Wang, Yi-Chen Lo. Inferring transcriptional compensation interactions in yeast via stepwise structure equation modeling. BMC Bioinformatics 9:134-143.
2007 Sanchita Krishna, Brant M. Wagenera, Hui Ping Liua, Yi-Chen Lo, Rosa Sterka, John H.J. Petrini, Jac A. Nickoloff. Mre11 and Ku regulation of double-strand break repair by gene conversion and break-induced replication. DNA repair 6: 797-808.
2006 Yi-Chen Lo, Kimberly S. Paffet, Or Amit, Jennifer A. Clikeman, Rosa Sterk, Mark A. Brenneman and Jac A. Nickoloff. Sgs1 Regulation of Gene Conversion Tract Lengths and Crossovers is Independent of ATP Hydrolysis. Molecular and Cellular Biology 26: 4086-4094.
2005  Lo, Y. C., Kurtz, R. B. & Nickoloff, J. A. Analysis of chromosome/allele loss in genetically unstable yeast by quantitative real-time PCR. Biotechniques 38, 685-690.
2000  Y-C. Lo, S. Mackenzie, A.F. Howie, D.K. Apps, J.I. Mason, B.C. Williams and S.D. Morley. Properties of an adrenal medullary protein immuno-related to steroidogenic acute regulatory (StAR) protein. Endocrine  Research 26 (4):737-748.
1999 Y-C. Lo, C.E. Gomez-Sanchez, C.J. Kenyon, J.I. Mason and B.C. Williams. Effects of dietary sodium on aldosterone synthase, 11b-hydroxylase and 3b-hydroxysteroid dehydrogenase expression in pregnant and foetal wistar rats. Molecular Steroidogenesis Frontiers Sciences Series No. 29:349-350.
1998 Y-C. Lo, L.Brett, C.J. Kenyon, S.D.Morley, J.I. Mason and B.C. Williams. StAR protein is expressed in both medulla and cortex of the bovine and rat adrenal gland. Endocrine Research 24(3&4): 559-563.
1996 Y.C. Lo and Y.F. Lu. Effect of deep frying oil and cholesterol on fatty acid composition in rat tissues. Food Science 23(2): 276-284.
1995 Y.C. Lo and Y.F. Lu. Effect of deep frying oil given with and without dietary cholesterol on lipid metabolism in rats. Nutrition Research 15(12):1783-1792.
1994 C.Y. Tang, H.L.Wu, Y.C. Lo and Y.F. Lu. Investigation on the contents of cholesterol oxides in commercial dried fishery products. Food Science 21(2): 107-113.
 
   
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計畫期間
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脂質代謝(lipid metabolism)
營養與遺傳(Nutrition and Genetics, Prenatal Programming)
分子內分泌學( Molecular Endocrinology)
基因修復 (DNA repair)
細胞週期的調節 (Cell cycle regulation)

 
輔仁大學 食品營養系營養組 學士 (1991)
輔仁大學 營養脂質代謝 碩士 (1993) 
英國愛丁堡大學臨床生化研究所博士 (2002)
副教授, 台灣大學食品科技研究所 8/ 2014-現在
助理教授, 台灣大學食品科技研究所  2/ 2008-8/ 2014
博士後研究員, 中央研究院細胞與個體生物學研究所  1/ 2007-1/2008
Associate Scientist, 美國新墨西哥州大學分子遺傳暨微生物學系  4/2005 –11/2006
博士後研究員, 美國新墨西哥州大學分子遺傳暨微生物學系  3/2002 –3/2005
講師, 台中中台醫事技術大學   8/1993 – 7/1997 
在職短期進修, 新竹食品工業研究所食品分析組  7/1995 – 8/1995
講師, 台中市衛生局 舉辦之社區營養與食品衛生講座  9/1994 – 2/1995
實習生, 台北市食品藥物檢驗局  7/1993 – 8/1993
實習生, 台北市國泰醫院營養室  7/1990 – 8/1990

 
教育部獎學金  1991-1993
Overseas Research Students Award in the United Kingdom  1998-2002
Wellcome Trust Travel grant for The ADRENAL 2000 and ENDO 2000 conferences, Toronto Canada 16th - 26th June,2000