台大食品科技研究所

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李月嘉
職稱 助理教授
姓名 李月嘉
聯絡電話 02-3366-4125
電子郵件
學歷 密西西比州立大學獸醫學博士 (2019)
研究專長 細菌生理學、
蛋白質體學、
食源性病原菌生物膜、
食品微生物汙染檢驗與防治
 
個人網址 https://yuejialee7.wixsite.com/leemicrobiologylab
  1. Lee Y. J., Abdullah, M., Chang, Y.F., Al Sudani, H. and Inzana, T.J., (2025). Characterization of proteins present in the biofilm matrix and outer membrane vesicles of Histophilus somni during iron-sufficient and iron-restricted growth: identification of potential protective antigens through in silico analyses. mBio, 16(5), e0064425.
  2. Lee Y. J., Cao D, Subhadra B, De Castro C, Speciale I, Inzana TJ. (2024). Relationship between capsule production and biofilm formation by Mannheimia haemolytica, and establishment of a poly-species biofilm with other Pasteurellaceae. Biofilm. 28;8:100223. 
  3. Hsu GC, Lin WJ, Hsieh CH, Lee Y. J., Sun SJ. (2024). Carcass size, not source or taxon, dictates breeding performance and carcass use in a burying beetle. Royal Society Open Science. 30;11(10):241265. 
  4. Cao D, Subhadra B, Lee Y. J., Thoresen M, Cornejo S, Olivier A, Woolums A, Inzana TJ. (2024). Contribution of Hfq to gene regulation and virulence in Histophilus somni. Infection and Immunity. 12;92(3):e0003824. 
  5. Lin Y., Chen C., Yang D., Wu Y., Lee Y. J., Chen Y., & Chen Y. (2023). Hepatic-Modulatory Effects of Chicken Liver Hydrolysate-Based Supplement on Autophagy Regulation against Liver Fibrogenesis. Antioxidants. 12(2):493.
  6. Budi Y. P., Hsu M. C., Lin Y. C., Lee Y. J., Chiu H. Y., Chiu C. H., & Jiang Y. F. (2023). The injections of mitochondrial fusion promoter M1 during proestrus disrupt the progesterone secretion and the estrous cycle in the mouse. Sci Rep. 10;13(1):2392.
  7. Lee, Y. J., & Inzana, T. J. (2021). Extraction and electrophoretic analysis of bacterial lipopolysaccharides and outer membrane proteins. Bio-protocol. 11(24), e4263. 
  8. Lee, Y. J., & Wang, C. (2020). Proteomic analysis reveals the temperature-dependent presence of extracytoplasmic peptidases in the biofilm exoproteome of Listeria monocytogenes EGD-e. Journal of Microbiology. 58(9), 761-771.
  9. Lee, Y. J., & Wang, C. (2020). Links between S-adenosylmethionine and Agr-based quorum sensing for biofilm development in Listeria monocytogenes EGD-e. MicrobiologyOpen, 9(5), e1015.
  10. Chiang C. M., Chiu H. Y., Jong D. S., Wu L. S., Lee Y. J. (Co-corresponding author), & Chiu C. H. (2020). Role of the Kisspeptin/KISS1 Receptor System in the Testicular Development of Mice. Journal of the Chinese Medical Association. 84(2), 203-211.
  11. Yang, W. Y., Lee, Y. J., Lu, H., Chou, C. H., & Wang, C. (2019). Analysis of contributory gut microbiota and lauric acid against necrotic enteritis in Clostridium perfringens and Eimeria side-by-side challenge model. PLOS One. 14(5), e0205784.
  12. Yang, W. Y., Lee, Y. J., Lu, H., Branton, S. L., Chou, C.H. & Wang, C. (2019). netB-positive Clostridium perfringens in the experimental induction of necrotic enteritis with or without predisposing factors. Poultry Science. pez311.
  13. Lee, Y. J. & Wang, C. (2017). Morphological change and decreasing transfer rate of biofilm-featured Listeria monocytogenes EGDe. Journal of Food Protection, 80(3), 368-375.
  14. Wang, J. Y., Lee, Y. J. (Co-first author), Chou, M. C., Chang, R., Chiu, C. H., Liang, Y. J., & Wu, L. S. (2015). Astaxanthin protects steroidogenesis from hydrogen peroxide-induced oxidative stress in mouse Leydig cells. Marine Drugs, 13(3), 1375-1388.
  15. Hsu, M. C., Wang, J. Y., Lee, Y. J., Jong, D. S., Tsui, K. H., & Chiu, C. H. (2014). Kisspeptin modulates fertilization capacity of mouse spermatozoa. Reproduction, 147(6), 835-845.
 
Oral presentations
  1. Zhao Z. & Lee Y-J “Impact of biofilm formation on foodborne pathogen’s responses to antimicrobial treatments.” 5th Faculty Forum of the University Consortium, Leyte, Philippines, September 2023. [Invited speaker]
  2. Lee Y-J, Wang C, & Inzana, TJ. “Understanding of the biofilm matrix and bacterial community behaviors to design more effective interventions for food contamination.” 4th Faculty Forum of the University Consortium, Nueva Ecija, Philippines, December 2022. [Invited speaker]
  3. Lee Y-J, Cao D, De Castro C, Molinaro A, Inzana TJ. Characterization of the Mannheimia haemolytica biofilm and poly-microbial interaction with other Pasteurellaceae. Annual Meeting of the Conference of Research Workers in Animal Diseases, Chicago, IL, December 2021.
  4. Lee Y-J, De Castro C, Molinaro A, Inzana TJ. In vitro characterization of poly-microbial biofilms by bovine respiratory disease pathogens. Annual Meeting of the Conference of Research Workers in Animal Diseases, Chicago, IL December 2020.
  5. Lee Y-J & Wang C. “Why is biofilm formation of Listeria monocytogenes a concern for food safety?” CVM Research Day at Mississippi State University, Mississippi State, MS, August 2018.
  6. Lee Y-J & Wang C. “Transferability and thermo-affected dispersion of biofilm-featured Listeria monocytogenes on stainless-steel surfaces.” CVM Research Day at Mississippi State University, Mississippi State, MS, August 2016.
Poster presentations
  1. Zhao Z & Lee Y-J. “Nisin Tolerance in Listeria monocytogenes Biofilms.” ASM Microbe 2025, Los Angeles, USA, June 2025
  2. Zhao Z & Lee Y-J. “Impact of biofilm formation on Listeria monocytogenes responses to nisin treatment.” 22nd IUFoST World Congress of Food Science and Technology, Rimini, Italy, September 2024
  3. Chen YR, Ting YW, Lee Y-J “Comparison of Antimicrobial Efficacy of Plasma-Activated Water against Listeria monocytogenes Grown in the Planktonic and Biofilm Modes.” IAFP, Toronto, Canada, July 2023
  4. Lee Y-J. “Effectiveness of proteolytic treatments on the control of Listeria monocytogenes biofilms.” 21st IUFoST World Congress of Food Science and Technology, Singapore, October 2022
  5. Lee Y-J, Cao D, De Castro C, Molinaro A, Inzana TJ. “Capsular polysaccharide interferes with biofilm formation in Mannheimia haemolytica serogroup A1.” World Microbe Forum, Online, June 2021
  6. Lee Y-J & Wang C. “Metabolite S-Adenosylmethionine directs Agr-based quorum sensing to enhance biofilm formation of Listeria monocytogenes.” American Society for Microbiology (ASM) Microbe, San Francisco, CA, USA, June 2019
  7. Lee Y-J & Wang C. “Thermo-effect on the biofilm dispersion of Listeria monocytogenes EGDe.” American Society for Microbiology (ASM) Microbe, New Orleans, LA, USA, June 2017
  8. Lee Y-J, Hsu MC, Jong DS, & Chiu CH. “The Physiological Function of Kisspeptin/GPR54 System in Mouse Leydig Cells” 29th Joint Annual Conference of Biomedical Science, Taiwan, March 2014  
  9. Lee Y-J, Huang YK, Wang JY, & Chiu CH. “The effect of Astaxanthin on steroidogenesis in H2O2-iduced oxidative stress MA-10 cell model.” 2nd Congress on Steroid Research, Chicago, IL, USA, March 2013
  10. Lee Y-J, Wang JY, & Chiu CH. “Study of Astaxanthin on steroidogenesis in H2O2-treated MA-10 tumor Leydig cells.” The Annual Meeting of Chinese Society of Animal Science, Taiwan, December 2010 [Young Scientist Poster Award]
  1. Project for junior researchers: Investigating metabolic basis of antimicrobial recalcitrance in foodborne pathogenic bacteria through single-cell transcriptomic analysis, funded by National Science and Technology Council, Taiwan, 2025-2028 [3-year grant]
  2. Project for junior researchers: Determinants and mechanisms underlying biofilm-induced tolerance and resistance of foodborne pathogens, funded by National Science and Technology Council, Taiwan, 2024-2025
  3. Project for junior researchers: Effect of Biofilm Formation on Foodborne Pathogen’s Responses to Antimicrobial Treatments: Insights from Listeria monocytogenes against a bacteriocin treatment, funded by National Science and Technology Council, Taiwan, 2023-2024
計畫期間
本實驗室研究主軸為食源性病菌與食品安全防治，內容包含食源性病菌之表面構造及生物膜生成探討，改良食源性病菌採樣與檢驗技術，以及利用生物膜模型和生化技術開發完善的生物膜偵測、防範及清除策略。本實驗室也與其他專業研究室及產業界合作，進行涵蓋食品微生物、食品加工、包裝和大數據分析之整合性研究，以促進食品安全文化的發展。

Current topics include:
1. Study of pathogenic biofilm development and microbial interactions
2. Develop strategies for intervening in pathogenic biofilm formation in the food industry
3. Food microbiome analysis using sequencing techniques

詳情請參考李博士個人網站
https://yuejialee7.wixsite.com/leemicrobiologylab

對本實驗室研究主題有興趣者(學生或研究員)，歡迎來信至 yuejialee7(at)ntu.edu.tw，與李博士聯絡。

2015/01 - 2019/08

博士, 美國密西西比州立大學 獸醫學院

2012/09 - 2014/06

碩士，國立臺灣大學 動物科學技術學系

2008/09 -2012/06

學士，國立臺灣大學 動物科學技術學系

2022/02 - 迄今

助理教授, 國立臺灣大學 食品科技所

2019/10 - 2022/01

博士後研究員, 美國長島大學 獸醫學院

本網站著作權屬於臺灣大學食品科技研究所，請詳見使用規則。

10617 台北市羅斯福路4段1號　
電話: (02) 3366-4109
傳真: (02) 2362-0849
E-Mail: fsatn@ntu.edu.tw
 

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