連絡方式

電話33669871

 


專長

食品與疾病預防,生物化學,分子生物學

 


研究領域

本實驗室的興趣在於利用分子生物技術,發展快速篩檢具保健功效之健康食品的平台。目前著重在篩檢對於代謝症侯群有調節效果的食品,並且研究其調控機轉。

 


教學課程

食品化學

食品蛋白質

食品生物化學

動物細胞實驗法

 


著作目錄

1.      Hsieh, S. C.; Lo, P. K.; Wang, F. F., Mouse DDA3 gene is a direct transcriptional target of p53 and p73. Oncogene 2002, 21, 3050-7.

2.      Tang, P. P.; Hsieh, S. C.; Wang, F. F., Modulation of caspase activation and p27(Kip1) degradation in the p53-induced apoptosis in IW32 erythroleukemia cells. Cellular signalling 2002, 14, 961-8.

3.      Hsieh, S. C.; Wang, F. F.; Hung, S. C.; Chen, Y. J.; Wang, Y. J., The internalized CdSe/ZnS quantum dots impair the chondrogenesis of bone marrow mesenchymal stem cells. Journal of biomedical materials research. Part B, Applied biomaterials 2006, 79, 95-101.

4.      Hsieh, S. C.; Wang, F. F.; Lin, C. S.; Chen, Y. J.; Hung, S. C.; Wang, Y. J., The inhibition of osteogenesis with human bone marrow mesenchymal stem cells by CdSe/ZnS quantum dot labels. Biomaterials 2006, 27, 1656-64.

5.      Hsieh, P. C.; Chang, J. C.; Sun, W. T.; Hsieh, S. C.; Wang, M. C.; Wang, F. F., p53 downstream target DDA3 is a novel microtubule-associated protein that interacts with end-binding protein EB3 and activates beta-catenin pathway. Oncogene 2007, 26, 4928-40.

6.      Hsieh, W. J.; Hsieh, S. C.; Chen, C. C.; Wang, F. F., Human DDA3 is an oncoprotein down-regulated by p53 and DNA damage. Biochemical and biophysical research communications 2008, 369, 567-72.

7.      Hsieh, S. C.; Chen, N. T.; Lo, S. H., Conditional loss of PTEN leads to skeletal abnormalities and lipoma formation. Molecular carcinogenesis 2009, 48, 545-52.

8.      Lin, K. L.; Chou, C. H.; Hsieh, S. C.; Hwa, S. Y.; Lee, M. T.; Wang, F. F., Transcriptional upregulation of DDR2 by ATF4 facilitates osteoblastic differentiation through p38 MAPK-mediated Runx2 activation. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2010, 25, 2489-503.

9.      Wang, H. C.; Yang, J. H.; Hsieh, S. C.; Sheen, L. Y., Allyl sulfides inhibit cell growth of skin cancer cells through induction of DNA damage mediated G2/M arrest and apoptosis. Journal of agricultural and food chemistry 2010, 58, 7096-103.

10.  Wang, T. M.; Chen, C. J.; Lee, T. S.; Chao, H. Y.; Wu, W. H.; Hsieh, S. C.; Sheu, H. H.; Chiang, A. N., Docosahexaenoic acid attenuates VCAM-1 expression and NF-kappaB activation in TNF-alpha-treated human aortic endothelial cells. The Journal of nutritional biochemistry 2011, 22, 187-94.

11.  Hsieh, W. J.; Chiou, S. T.; Pan, M. H.; Hsieh, S. C., Establishment and evaluation of biotechnological platform for screening health food with anti-inflammation ability. Journal of Traditional and Complementary Medicine 2012, 2, 76-80

12.  Wang, H. C.; Hsieh, S. C.; Yang, J. H.; Lin, S. Y.; Sheen, L. Y., Diallyl trisulfide induces apoptosis of human basal cell carcinoma cells via endoplasmic reticulum stress and the mitochondrial pathway. Nutrition and cancer 2012, 64, 770-80. 13.

13.  Wang, M. E.; Chen, Y. C.; Chen, I. S.; Hsieh, S. C.; Chen, S. S.; Chiu, C. H., Curcumin protects against thioacetamide-induced hepatic fibrosis by attenuating the inflammatory response and inducing apoptosis of damaged hepatocytes. The Journal of nutritional biochemistry 2012, 23, 1352-66.

14.  Pua, X. H.; Lee, M. C.; Hsieh, S. C.; Yu, T. C.; Chen, K. C., Conceptual design of an industrial-scale plant for ethanol production form taro waste. 臺灣農業化學與食品科學 2012, 51, 176-186.

15.  Chang, Y. C.; Tsai, M. H.; Sheu, W. H.; Hsieh, S. C.; Chiang, A. N., The therapeutic potential and mechanisms of action of quercetin in relation to lipopolysaccharide-induced sepsis in vitro and in vivo. PloS one 2013, 8, e80744.

16.  Hsieh, S. C.; Kuo, S. N.; Zheng, Y. H.; Tsai, M. H.; Lin, Y. S.; Lin, J. H., The E3 ubiquitin ligase SIAH2 is a prosurvival factor overexpressed in oral cancer. Anticancer research 2013, 33, 4965-73.

17.  Hsu, C. H.; Ho, Y. S.; Lai, C. S.; Hsieh, S. C.; Chen, L. H.; Lin, E.; Ho, C. T.; Pan, M. H., Hexahydro-beta-acids potently inhibit 12-O-tetradecanoylphorbol 13-acetate-induced skin inflammation and tumor promotion in mice. Journal of agricultural and food chemistry 2013, 61, 11541-9.

18.  Lai, L. R.; Hsieh, S. C.; Huang, H. Y.; Chou, C. C., Effect of lactic fermentation on the total phenolic, saponin and phytic acid contents as well as anti-colon cancer cell proliferation activity of soymilk. Journal of bioscience and bioengineering 2013, 115, 552-6.

19.  Lin, J. H.; Hsieh, S. C.; Chen, J. N.; Tsai, M. H.; Chang, C. C., WWP1 gene is a potential molecular target of human oral cancer. Oral surgery, oral medicine, oral pathology and oral radiology 2013, 116, 221-31.

20.  Lin, M. H.; Tsai, T. Y.; Hsieh, S. C.; Yu, R. C.; Chou, C. C., Susceptibility of Vibrio parahaemolyticus to disinfectants after prior exposure to sublethal stress. Food microbiology 2013, 34, 202-6.

21.  Wang, C. H.; Lin, J. H.; Lu, T. J.; Chiang, A. N.; Chiou, S. T.; Chen, Y. A.; Pan, M. H.; Hsieh, S. C., Establishment of reporter platforms capable of detecting NF-kappaB mediated immuno-modulatory activity. Journal of agricultural and food chemistry 2013, 61, 12582-7.

22.    Wang, K. W.; Chueh, L. L.; Wang, M. H.; Huang, Y. T.; Fang, B. H.; Chang, C. Y.; Fang, M. C.; Chou, J. Y.; Hsieh, S. C.; Wan, C. H., Multiplex polymerase chain reaction assay for the detection of minute virus of mice and mouse parvovirus infections in laboratory mice. Laboratory animals 2013, 47, 116-21.

23.  Wang, T. M.; Hsieh, S. C.; Chen, J. W.; Chiang, A. N., Docosahexaenoic acid and eicosapentaenoic acid reduce C-reactive protein expression and STAT3 activation in IL-6-treated HepG2 cells. Molecular and cellular biochemistry 2013, 377, 97-106.

24.  Hsieh, C. C.; Hsieh, S. C.; Chiu, J. H.; Wu, Y. L., Preconditioning somatothermal stimulation on Qimen (LR14) reduces hepatic ischemia/reperfusion injury in rats. BMC complementary and alternative medicine 2014, 14, 18.

25.  Hsieh, C. C.; Hsieh, S. C.; Chiud, J. H.; Wu, Y. L., Protective effects of N-acetylcysteine and a Prostaglandin E1 analogue, Alprostadil, against Hepatic Ischemia–Reperfusion Injury in Rats. . Journal of Traditional and Complementary Medicine 2014, 4, 64-71.

26.  Lin, S. P.; Hsieh, S. C.; Chen, K. I.; Demirci, A.; Cheng, K. C., Semi-continuous bacterial cellulose production in a rotating disk bioreactor and its materials properties analysis. Cellulose 2014, 21, 835-844.

27.  Wang, C. H.; Hsieh, S. C.; Wang, H. J.; Chen, M. L.; Lin, B. F.; Chiang, B. H.; Lu, T. J., Concentration Variation and Molecular Characteristics of Soluble (1,3;1,6)-beta-d-Glucans in Submerged Cultivation Products of Ganoderma lucidum Mycelium. Journal of agricultural and food chemistry 2014, 62, 634-641.

28.  Weerawatanakorn, M.; Hsieh, S. C.; Tsai, M. L.; Lai, C. S.; Wu, L. M.; Badmaev, V.; Ho, C. T.; Pan, M. H., Inhibitory effect of tetrahydrocurcumin on dimethylnitrosamine-induced liver fibrosis in rats. Journal of Functional Foods 2014, 7, 305-313.

29.  Lin, S. H., Chen, W. C., Lu, K. H., Chen, P. J., Hsieh, S. C., Pan, T. M., Chen, S.T., Sheen, L.Y.,Down-regulation of Slit-Robo pathway mediating neuronal cytoskeletal remodeling processes facilitates the antidepressive-like activity of Gastrodia elata Blume. Journal of agricultural and food chemistry 2014, 62, 634-641.

30.  Lo, W.Y., Sheen, L.Y., Lo, Y. C., Hsieh, S. C., The effect of blackcurrant on anti-inflammation and prevnetion of allergic respieratory diseases syndrome. Taiwanese jouranl of agricultural chemistry and food science 2014, 52(1), 25-30.

31.  Huang, C. Y.; Chen, W. M.; Tsay, Y. G.; Hsieh, S. C.; Lin, Y.; Lee, W. J., Sheu, W. H.; Chiang, A. N., Differential regulation of protein expression in response to polyunsaturated fatty acids in the liver of apoE-knockout mice and in HepG2 cells. Journal of biomedical science 2015, 22, 12.

32.  Hsieh, C.C., Hsu, S. M., Hwang, L. S., Chiu, J. C., Lu, W. C., Wu, Y. L., Hsieh, S. C., Protective effects of the extract from longan flower against hepatic ischemia/reperfusion injury in rats. Journal of functional foods 2015, 12, 570-579.